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10.1242/dmm.046581

http://scihub22266oqcxt.onion/10.1242/dmm.046581
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32887790!7490513!32887790
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suck abstract from ncbi


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pmid32887790      Dis+Model+Mech 2020 ; 13 (9): ä
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  • Cell and animal models of SARS-CoV-2 pathogenesis and immunity #MMPMID32887790
  • Leist SR; Schafer A; Martinez DR
  • Dis Model Mech 2020[Sep]; 13 (9): ä PMID32887790show ga
  • The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic.
  • |Animals[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/drug effects/*immunology/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Cells, Cultured[MESH]
  • |Coronavirus Infections/drug therapy/*immunology/prevention & control/*virology[MESH]
  • |Disease Models, Animal[MESH]
  • |Host Microbial Interactions[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/*immunology/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Species Specificity[MESH]
  • |Tissue Culture Techniques[MESH]


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