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10.1084/jem.20200872 http://scihub22266oqcxt.onion/10.1084/jem.20200872 32886755!7472174!32886755     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2020 ; 217 (12): ä Nephropedia Template TP {{tp|p=32886755|t=2020. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |pdf=|usr=}}{{32886755}} gab.com Text Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32886755 #FOAvip COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, gammadeltaT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS. Twit Text FOAVip Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32886755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32886755 #FOAvip English Wikipedia <ref>{{Cite pmid|32886755}}</ref> Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients #MMPMID32886755 Jouan Y; Guillon A; Gonzalez L; Perez Y; Boisseau C; Ehrmann S; Ferreira M; Daix T; Jeannet R; Francois B; Dequin PF; Si-Tahar M; Baranek T; Paget C J Exp Med 2020[Dec]; 217 (12): ä PMID32886755show ga COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, gammadeltaT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS. |*Phenotype[MESH] |Aged[MESH] |Antigens, CD/blood[MESH] |Antigens, Differentiation, T-Lymphocyte/blood[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation/immunology/metabolism[MESH] |Lectins, C-Type/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Mucosal-Associated Invariant T Cells/immunology/*metabolism[MESH] |Natural Killer T-Cells/immunology/*metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |Receptors, Antigen, T-Cell, gamma-delta/*metabolism[MESH] |Respiratory Distress Syndrome/*immunology/virology[MESH] |SARS-CoV-2[MESH]Phenotypical and functional alteration of unconventional T cells in se(epmc).pdf DeepDyve Pubget Overpricing