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10.1007/s15010-020-01516-2

http://scihub22266oqcxt.onion/10.1007/s15010-020-01516-2
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32886331!7472674!32886331
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suck abstract from ncbi


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pmid32886331      Infection 2021 ; 49 (2): 199-213
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  • COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics #MMPMID32886331
  • Yesudhas D; Srivastava A; Gromiha MM
  • Infection 2021[Apr]; 49 (2): 199-213 PMID32886331show ga
  • PURPOSE: The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and the structural characteristics of the spike protein and its key residues responsible for human transmissions. METHODS: We have carried out a systematic review to summarize the origin, transmission and etiology of COVID-19. The structural analysis of the spike protein and its disordered residues explains the mechanism of the viral transmission. A meta-data analysis of the therapeutic compounds targeting the SARS-CoV-2 is also included. RESULTS: Coronaviruses can cross the species barrier and infect humans with unexpected consequences for public health. The transmission rate of SARS-CoV-2 infection is higher compared to that of the closely related SARS-CoV infections. In SARS-CoV-2 infection, intrinsically disordered regions are observed at the interface of the spike protein and ACE2 receptor, providing a shape complementarity to the complex. The key residues of the spike protein have stronger binding affinity with ACE2. These can be probable reasons for the higher transmission rate of SARS-CoV-2. In addition, we have also discussed the therapeutic compounds and the vaccines to target SARS-CoV-2, which can help researchers to develop effective drugs/vaccines for COVID-19. The overall history and mechanism of entry of SARS-CoV-2 along with structural study of spike-ACE2 complex provide insights to understand disease pathogenesis and development of vaccines and drugs.
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/epidemiology/*transmission/*virology[MESH]
  • |Coronavirus Infections/drug therapy/epidemiology/transmission/virology[MESH]
  • |Humans[MESH]
  • |Protein Binding[MESH]
  • |Protein Folding[MESH]
  • |SARS-CoV-2/chemistry/metabolism/*physiology[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/genetics/*metabolism[MESH]


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