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10.1016/j.virol.2020.07.015 http://scihub22266oqcxt.onion/10.1016/j.virol.2020.07.015 32882638!7443325!32882638     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2020 ; 550 (ä): 61-69 Nephropedia Template TP {{tp|p=32882638|t=2020. Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2 |pdf=|usr=}}{{32882638}} gab.com Text Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2 JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=32882638 #FOAvip The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and use this to inform a possible mathematical formulation of the effect of remdesivir. Unfortunately, this model formulation suggests that the application of remdesivir will lengthen SARS-CoV-2 infections, putting into question its potential clinical benefit. Twit Text FOAVip Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2 ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=32882638 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32882638 #FOAvip English Wikipedia <ref>{{Cite pmid|32882638}}</ref> Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2 #MMPMID32882638 Dobrovolny HM Virology 2020[Nov]; 550 (ä): 61-69 PMID32882638show ga The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and use this to inform a possible mathematical formulation of the effect of remdesivir. Unfortunately, this model formulation suggests that the application of remdesivir will lengthen SARS-CoV-2 infections, putting into question its potential clinical benefit. |*Models, Statistical[MESH] |Adenosine Monophosphate/*analogs & derivatives/blood/pharmacokinetics[MESH] |Alanine/*analogs & derivatives/blood/pharmacokinetics[MESH] |Animals[MESH] |Antiviral Agents/blood/*pharmacokinetics[MESH] |Betacoronavirus/*drug effects/growth & development/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/*drug therapy/virology[MESH] |Disease Models, Animal[MESH] |Drug Administration Schedule[MESH] |Humans[MESH] |Inflammation[MESH] |Macaca mulatta[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*drug therapy/virology[MESH] |SARS-CoV-2[MESH] |Viral Load[MESH]Quantifying the effect of remdesivir in rhesus macaques infected with (epmc).pdf DeepDyve Pubget Overpricing