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10.1016/j.gene.2020.145102 http://scihub22266oqcxt.onion/10.1016/j.gene.2020.145102 32882331!7456966!32882331     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2020 ; 762 (ä): 145102 Nephropedia Template TP {{tp|p=32882331|t=2020. Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome |pdf=|usr=}}{{32882331}} gab.com Text Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=32882331 #FOAvip The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuals susceptibility to infection. In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play a role in the severity of COVID-19. Functional ACE1/ACE2 gene polymorphisms have been associated with the risk of cardiovascular and pulmonary diseases, and could thus also contribute to the outcome of COVID-19. We studied 204 COVID-19 patients (137 non-severe and 67 severe-ICU cases) and 536 age-matched controls. The ACE1 insertion/deletion and ACE2 rs2285666 polymorphism were determined. Variables frequencies were compared between the groups by logistic regression. We also sequenced the ACE2 coding nucleotides in a group of patients. Severe COVID-19 was associated with hypertension male gender (p < 0.001), hypertension (p = 0.006), hypercholesterolaemia (p = 0.046), and the ACE1-DD genotype (p = 0.049). In the multiple logistic regression hypertension (p = 0.02, OR = 2.26, 95%CI = 1.12-4.63) and male gender (p = 0.002; OR = 3.15, 95%CI = 1.56-6.66) remained as independent significant predictors of severity. The ACE2 polymorphism was not associated with the disease outcome. The ACE2 sequencing showed no coding sequence variants that could explain an increased risk of developing COVID-19. In conclusion, an adverse outcome of COVID-19 was associated with male gender, hypertension, hypercholesterolemia and the ACE1 genotype. Our work suggested that the ACE1-I/D might influence COVID-19 severity, but the effect was dependent on the hypertensive status. This result requires further validation in other large cohorts. Twit Text FOAVip Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=32882331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32882331 #FOAvip English Wikipedia <ref>{{Cite pmid|32882331}}</ref> Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome #MMPMID32882331 Gomez J; Albaiceta GM; Garcia-Clemente M; Lopez-Larrea C; Amado-Rodriguez L; Lopez-Alonso I; Hermida T; Enriquez AI; Herrero P; Melon S; Alvarez-Arguelles ME; Boga JA; Rojo-Alba S; Cuesta-Llavona E; Alvarez V; Lorca R; Coto E Gene 2020[Dec]; 762 (ä): 145102 PMID32882331show ga The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuals susceptibility to infection. In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play a role in the severity of COVID-19. Functional ACE1/ACE2 gene polymorphisms have been associated with the risk of cardiovascular and pulmonary diseases, and could thus also contribute to the outcome of COVID-19. We studied 204 COVID-19 patients (137 non-severe and 67 severe-ICU cases) and 536 age-matched controls. The ACE1 insertion/deletion and ACE2 rs2285666 polymorphism were determined. Variables frequencies were compared between the groups by logistic regression. We also sequenced the ACE2 coding nucleotides in a group of patients. Severe COVID-19 was associated with hypertension male gender (p < 0.001), hypertension (p = 0.006), hypercholesterolaemia (p = 0.046), and the ACE1-DD genotype (p = 0.049). In the multiple logistic regression hypertension (p = 0.02, OR = 2.26, 95%CI = 1.12-4.63) and male gender (p = 0.002; OR = 3.15, 95%CI = 1.56-6.66) remained as independent significant predictors of severity. The ACE2 polymorphism was not associated with the disease outcome. The ACE2 sequencing showed no coding sequence variants that could explain an increased risk of developing COVID-19. In conclusion, an adverse outcome of COVID-19 was associated with male gender, hypertension, hypercholesterolemia and the ACE1 genotype. Our work suggested that the ACE1-I/D might influence COVID-19 severity, but the effect was dependent on the hypertensive status. This result requires further validation in other large cohorts. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/*genetics[MESH] |Female[MESH] |Genotyping Techniques[MESH] |Humans[MESH] |Hypercholesterolemia/complications[MESH] |Hypertension/complications[MESH] |INDEL Mutation[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |Pneumonia, Viral/*genetics[MESH] |Polymorphism, Single Nucleotide[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Spain[MESH]Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 (epmc).pdf DeepDyve Pubget Overpricing