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10.1089/jir.2020.0105

http://scihub22266oqcxt.onion/10.1089/jir.2020.0105
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32881593!ä!32881593

suck abstract from ncbi


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pmid32881593      J+Interferon+Cytokine+Res 2020 ; 40 (10): 469-471
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  • Impact of Hydroxychloroquine/Chloroquine in COVID-19 Therapy: Two Sides of the Coin #MMPMID32881593
  • Fatima U; Rizvi SSA; Fatima S; Hassan MI
  • J Interferon Cytokine Res 2020[Oct]; 40 (10): 469-471 PMID32881593show ga
  • Coronavirus disease 2019 (COVID-19), which is caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has recently emerged as a global health threat. To address this health emergency, various therapeutic approaches are currently under investigation. There is limited evidence on the effectiveness of hydroxychloroquine (HCQ) and chloroquine (CQ) as COVID-19 therapies, and thus World Health Organization (WHO) mentioned that "Current data shows that this drug does not reduce deaths among hospitalized COVID-19 patients, nor help people with mild or moderate disease." CQ and HCQ are typically used for the treatment of malaria but have been recognized for certain beneficial effects in COVID-19 patients based on some clinical outcomes from the clinical treatment of COVID-19. A standard dose of HCQ has been proven effective and less toxic than CQ in COVID-19 patients; however, a comprehensive understanding of a patient's clinical condition is necessary. Based on several hospital findings, the Food and Drug Administration (FDA) has officially cancelled the emergency use authorization for HCQ and CQ for treating hospitalized COVID-19 patients on June 15, 2020. In this review, we highlight both pros and cons of the clinical use of CQ and HCQ in COVID-19 patients.
  • |Anti-Infective Agents/*administration & dosage/adverse effects[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/growth & development/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Chloroquine/*administration & dosage/adverse effects[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/*drug therapy/pathology/virology[MESH]
  • |Drug Synergism[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*administration & dosage/adverse effects[MESH]
  • |Immunologic Factors/*administration & dosage/adverse effects[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/pathology/virology[MESH]
  • |SARS-CoV-2[MESH]


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