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10.1002/1873-3468.13908 http://scihub22266oqcxt.onion/10.1002/1873-3468.13908 32880920!7461230!32880920     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2020 ; 594 (20): 3363-3370 Nephropedia Template TP {{tp|p=32880920|t=2020. Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19 |pdf=|usr=}}{{32880920}} gab.com Text Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19 JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=32880920 #FOAvip We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that MPS cells might be less, rather than more, susceptible to SARS-CoV-2 infection. Twit Text FOAVip Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19 ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=32880920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32880920 #FOAvip English Wikipedia <ref>{{Cite pmid|32880920}}</ref> Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19 #MMPMID32880920 Pierzynowska K; Gaffke L; Wegrzyn G FEBS Lett 2020[Oct]; 594 (20): 3363-3370 PMID32880920show ga We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that MPS cells might be less, rather than more, susceptible to SARS-CoV-2 infection. |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |COVID-19/*genetics/metabolism/pathology/prevention & control[MESH] |Cells, Cultured[MESH] |Fibroblasts/metabolism/pathology/virology[MESH] |Gene Expression Profiling[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Mucopolysaccharidoses/*genetics/metabolism/pathology/virology[MESH] |SARS-CoV-2/pathogenicity/*physiology[MESH] |Serine Endopeptidases/genetics/metabolism[MESH]Transcriptomic analyses suggest that mucopolysaccharidosis patients ma(epmc).pdf DeepDyve Pubget Overpricing