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10.7759/cureus.10103 http://scihub22266oqcxt.onion/10.7759/cureus.10103 32879833!7456627!32879833     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cureus 2020 ; 12 (8): e10103 Nephropedia Template TP {{tp|p=32879833|t=2020. Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations |pdf=|usr=}}{{32879833}} gab.com Text Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations JO: Cureus http://www.kidney.de/pget.php?&tw=1&pmid=32879833 #FOAvip Background Prevalence and mortality rates during the coronavirus disease 2019 (COVID-19) pandemic have varied widely across nations. This phenomenon may be partly due to regional variations in health-related behaviours, some of which may be influenced by health anxiety. A functional polymorphism of the catechol O-methyltransferase (COMT) gene, designated rs4680 or Val(158)Met, has been associated with anxiety-related behaviours and the so-called "worrier" phenotype. Methods In this exploratory study, an analysis of the correlation between the frequencies of the Met allele of the COMT gene across 28 countries, obtained from the public domain Allele Frequency Database (ALFRED), and the COVID-19 prevalence and mortality rates in these countries, obtained from the Johns Hopkins Medical University web-based dashboard, was carried out while controlling for population size and median age in each country. Results Allele frequencies varied widely across populations. Met allele frequency was positively correlated with COVID-19 prevalence (rho = 0.527, p = 0.004) and mortality rate (rho = 0.542, p = 0.003) across nations. However, this correlation was no longer significant after controlling for confounders. Conclusions These preliminary results suggest that there may be a relationship between the COMT Val(158)Met or rs4680 functional polymorphism and the impact of COVID-19 across nations, which could plausibly be mediated by maladaptive anxiety-related behaviours. Twit Text FOAVip Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations ????Cureus http://www.kidney.de/pget.php?&tw=1&pmid=32879833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32879833 #FOAvip English Wikipedia <ref>{{Cite pmid|32879833}}</ref> Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations #MMPMID32879833 Rajkumar RP Cureus 2020[Aug]; 12 (8): e10103 PMID32879833show ga Background Prevalence and mortality rates during the coronavirus disease 2019 (COVID-19) pandemic have varied widely across nations. This phenomenon may be partly due to regional variations in health-related behaviours, some of which may be influenced by health anxiety. A functional polymorphism of the catechol O-methyltransferase (COMT) gene, designated rs4680 or Val(158)Met, has been associated with anxiety-related behaviours and the so-called "worrier" phenotype. Methods In this exploratory study, an analysis of the correlation between the frequencies of the Met allele of the COMT gene across 28 countries, obtained from the public domain Allele Frequency Database (ALFRED), and the COVID-19 prevalence and mortality rates in these countries, obtained from the Johns Hopkins Medical University web-based dashboard, was carried out while controlling for population size and median age in each country. Results Allele frequencies varied widely across populations. Met allele frequency was positively correlated with COVID-19 prevalence (rho = 0.527, p = 0.004) and mortality rate (rho = 0.542, p = 0.003) across nations. However, this correlation was no longer significant after controlling for confounders. Conclusions These preliminary results suggest that there may be a relationship between the COMT Val(158)Met or rs4680 functional polymorphism and the impact of COVID-19 across nations, which could plausibly be mediated by maladaptive anxiety-related behaviours. äWarriors, Worriers, and COVID-19: An Exploratory Study of the Catechol(epmc).pdf DeepDyve Pubget Overpricing