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10.1101/gr.266221.120 http://scihub22266oqcxt.onion/10.1101/gr.266221.120 32878977!7605265!32878977     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2020 ; 30 (10): 1434-1448 Nephropedia Template TP {{tp|p=32878977|t=2020. Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders |pdf=|usr=}}{{32878977}} gab.com Text Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=32878977 #FOAvip The human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the major pandemic of the twenty-first century. We analyzed more than 4700 SARS-CoV-2 genomes and associated metadata retrieved from public repositories. SARS-CoV-2 sequences have a high sequence identity (>99.9%), which drops to >96% when compared to bat coronavirus genome. We built a mutation-annotated reference SARS-CoV-2 phylogeny with two main macro-haplogroups, A and B, both of Asian origin, and more than 160 sub-branches representing virus strains of variable geographical origins worldwide, revealing a rather uniform mutation occurrence along branches that could have implications for diagnostics and the design of future vaccines. Identification of the root of SARS-CoV-2 genomes is not without problems, owing to conflicting interpretations derived from either using the bat coronavirus genomes as an outgroup or relying on the sampling chronology of the SARS-CoV-2 genomes and TMRCA estimates; however, the overall scenario favors haplogroup A as the ancestral node. Phylogenetic analysis indicates a TMRCA for SARS-CoV-2 genomes dating to November 12, 2019, thus matching epidemiological records. Sub-haplogroup A2 most likely originated in Europe from an Asian ancestor and gave rise to subclade A2a, which represents the major non-Asian outbreak, especially in Africa and Europe. Multiple founder effect episodes, most likely associated with super-spreader hosts, might explain COVID-19 pandemic to a large extent. Twit Text FOAVip Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=32878977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32878977 #FOAvip English Wikipedia <ref>{{Cite pmid|32878977}}</ref> Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders #MMPMID32878977 Gomez-Carballa A; Bello X; Pardo-Seco J; Martinon-Torres F; Salas A Genome Res 2020[Oct]; 30 (10): 1434-1448 PMID32878977show ga The human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the major pandemic of the twenty-first century. We analyzed more than 4700 SARS-CoV-2 genomes and associated metadata retrieved from public repositories. SARS-CoV-2 sequences have a high sequence identity (>99.9%), which drops to >96% when compared to bat coronavirus genome. We built a mutation-annotated reference SARS-CoV-2 phylogeny with two main macro-haplogroups, A and B, both of Asian origin, and more than 160 sub-branches representing virus strains of variable geographical origins worldwide, revealing a rather uniform mutation occurrence along branches that could have implications for diagnostics and the design of future vaccines. Identification of the root of SARS-CoV-2 genomes is not without problems, owing to conflicting interpretations derived from either using the bat coronavirus genomes as an outgroup or relying on the sampling chronology of the SARS-CoV-2 genomes and TMRCA estimates; however, the overall scenario favors haplogroup A as the ancestral node. Phylogenetic analysis indicates a TMRCA for SARS-CoV-2 genomes dating to November 12, 2019, thus matching epidemiological records. Sub-haplogroup A2 most likely originated in Europe from an Asian ancestor and gave rise to subclade A2a, which represents the major non-Asian outbreak, especially in Africa and Europe. Multiple founder effect episodes, most likely associated with super-spreader hosts, might explain COVID-19 pandemic to a large extent. |Animals[MESH] |Asia/epidemiology[MESH] |Base Sequence/genetics[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Chiroptera/virology[MESH] |Chromosome Mapping[MESH] |Coronavirus Infections/*epidemiology[MESH] |Europe/epidemiology[MESH] |Evolution, Molecular[MESH] |Genetic Variation/genetics[MESH] |Genome, Viral/*genetics[MESH] |Humans[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Phylogeography[MESH] |Pneumonia, Viral/*epidemiology[MESH] |SARS-CoV-2[MESH]Mapping genome variation of SARS-CoV-2 worldwide highlights the impact(epmc).pdf DeepDyve Pubget Overpricing