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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Microorganisms 2020 ; 8 (9): ä Nephropedia Template TP
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Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids #MMPMID32878286
D'Ardes D; Pontolillo M; Esposito L; Masciarelli M; Boccatonda A; Rossi I; Bucci M; Guagnano MT; Ucciferri C; Santilli F; Di Nicola M; Falasca K; Vecchiet J; Schael T; Cipollone F
Microorganisms 2020[Aug]; 8 (9): ä PMID32878286show ga
The diffusion of SARS-CoV-2, starting from China in December 2019, has led to a pandemic, reaching Italy in February 2020. Previous studies in Asia have shown that the median duration of SARS-CoV-2 viral shedding was approximately 12-20 days. We considered a cohort of patients recovered from COVID-19 showing that the median disease duration between onset and end of COVID-19 symptoms was 27.5 days (interquartile range (IQR): 17.0-33.2) and that the median duration between onset of symptoms and microbiological healing, defined by two consecutive negative nasopharyngeal swabs, was 38 days (IQR: 31.7-50.2). A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO(2)/FiO(2) ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). Moreover, patients presenting at admission a lower PaO(2)/FiO(2) ratio and more severe disease showed longer viral shedding (p = 0.031 and p = 0.032, respectively). In addition, patients treated with corticosteroids had delayed clinical healing (p = 0.013).