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10.1016/j.cell.2020.08.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.08.025 32877699!7437499!32877699     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (1): 143-157.e13 Nephropedia Template TP {{tp|p=32877699|t=2020. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 |pdf=|usr=}}{{32877699}} gab.com Text Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32877699 #FOAvip Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined post mortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers and a striking reduction in Bcl-6(+) germinal center B cells but preservation of AID(+) B cells. Absence of germinal centers correlated with an early specific block in Bcl-6(+) T(FH) cell differentiation together with an increase in T-bet(+) T(H1) cells and aberrant extra-follicular TNF-alpha accumulation. Parallel peripheral blood studies revealed loss of transitional and follicular B cells in severe disease and accumulation of SARS-CoV-2-specific "disease-related" B cell populations. These data identify defective Bcl-6(+) T(FH) cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections, and suggest that achieving herd immunity through natural infection may be difficult. Twit Text FOAVip Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32877699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32877699 #FOAvip English Wikipedia <ref>{{Cite pmid|32877699}}</ref> Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 #MMPMID32877699 Kaneko N; Kuo HH; Boucau J; Farmer JR; Allard-Chamard H; Mahajan VS; Piechocka-Trocha A; Lefteri K; Osborn M; Bals J; Bartsch YC; Bonheur N; Caradonna TM; Chevalier J; Chowdhury F; Diefenbach TJ; Einkauf K; Fallon J; Feldman J; Finn KK; Garcia-Broncano P; Hartana CA; Hauser BM; Jiang C; Kaplonek P; Karpell M; Koscher EC; Lian X; Liu H; Liu J; Ly NL; Michell AR; Rassadkina Y; Seiger K; Sessa L; Shin S; Singh N; Sun W; Sun X; Ticheli HJ; Waring MT; Zhu AL; Alter G; Li JZ; Lingwood D; Schmidt AG; Lichterfeld M; Walker BD; Yu XG; Padera RF Jr; Pillai S Cell 2020[Oct]; 183 (1): 143-157.e13 PMID32877699show ga Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined post mortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers and a striking reduction in Bcl-6(+) germinal center B cells but preservation of AID(+) B cells. Absence of germinal centers correlated with an early specific block in Bcl-6(+) T(FH) cell differentiation together with an increase in T-bet(+) T(H1) cells and aberrant extra-follicular TNF-alpha accumulation. Parallel peripheral blood studies revealed loss of transitional and follicular B cells in severe disease and accumulation of SARS-CoV-2-specific "disease-related" B cell populations. These data identify defective Bcl-6(+) T(FH) cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections, and suggest that achieving herd immunity through natural infection may be difficult. |Aged[MESH] |Aged, 80 and over[MESH] |B-Lymphocytes/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology[MESH] |Female[MESH] |Germinal Center/*immunology/pathology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology[MESH] |Proto-Oncogene Proteins c-bcl-6/genetics/metabolism[MESH] |Spleen/immunology/pathology[MESH] |T-Lymphocytes, Helper-Inducer/*immunology[MESH]Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Center(epmc).pdf DeepDyve Pubget Overpricing