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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+One 2020 ; 15 (9): e0238342 Nephropedia Template TP
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Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States #MMPMID32877446
Burke RM; Balter S; Barnes E; Barry V; Bartlett K; Beer KD; Benowitz I; Biggs HM; Bruce H; Bryant-Genevier J; Cates J; Chatham-Stephens K; Chea N; Chiou H; Christiansen D; Chu VT; Clark S; Cody SH; Cohen M; Conners EE; Dasari V; Dawson P; DeSalvo T; Donahue M; Dratch A; Duca L; Duchin J; Dyal JW; Feldstein LR; Fenstersheib M; Fischer M; Fisher R; Foo C; Freeman-Ponder B; Fry AM; Gant J; Gautom R; Ghinai I; Gounder P; Grigg CT; Gunzenhauser J; Hall AJ; Han GS; Haupt T; Holshue M; Hunter J; Ibrahim MB; Jacobs MW; Jarashow MC; Joshi K; Kamali T; Kawakami V; Kim M; Kirking HL; Kita-Yarbro A; Klos R; Kobayashi M; Kocharian A; Lang M; Layden J; Leidman E; Lindquist S; Lindstrom S; Link-Gelles R; Marlow M; Mattison CP; McClung N; McPherson TD; Mello L; Midgley CM; Novosad S; Patel MT; Pettrone K; Pillai SK; Pray IW; Reese HE; Rhodes H; Robinson S; Rolfes M; Routh J; Rubin R; Rudman SL; Russell D; Scott S; Shetty V; Smith-Jeffcoat SE; Soda EA; Spitters C; Stierman B; Sunenshine R; Terashita D; Traub E; Vahey GM; Verani JR; Wallace M; Westercamp M; Wortham J; Xie A; Yousaf A; Zahn M
PLoS One 2020[]; 15 (9): e0238342 PMID32877446show ga
Coronavirus disease 2019 (COVID-19), the respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. In response to the first cases identified in the United States, close contacts of confirmed COVID-19 cases were investigated to enable early identification and isolation of additional cases and to learn more about risk factors for transmission. Close contacts of nine early travel-related cases in the United States were identified and monitored daily for development of symptoms (active monitoring). Selected close contacts (including those with exposures categorized as higher risk) were targeted for collection of additional exposure information and respiratory samples. Respiratory samples were tested for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction at the Centers for Disease Control and Prevention. Four hundred four close contacts were actively monitored in the jurisdictions that managed the travel-related cases. Three hundred thirty-eight of the 404 close contacts provided at least basic exposure information, of whom 159 close contacts had >/=1 set of respiratory samples collected and tested. Across all actively monitored close contacts, two additional symptomatic COVID-19 cases (i.e., secondary cases) were identified; both secondary cases were in spouses of travel-associated case patients. When considering only household members, all of whom had >/=1 respiratory sample tested for SARS-CoV-2, the secondary attack rate (i.e., the number of secondary cases as a proportion of total close contacts) was 13% (95% CI: 4-38%). The results from these contact tracing investigations suggest that household members, especially significant others, of COVID-19 cases are at highest risk of becoming infected. The importance of personal protective equipment for healthcare workers is also underlined. Isolation of persons with COVID-19, in combination with quarantine of exposed close contacts and practice of everyday preventive behaviors, is important to mitigate spread of COVID-19.
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PLoS+One 2020 ; 15 (9): e0238342
