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10.15252/embj.2020106230 http://scihub22266oqcxt.onion/10.15252/embj.2020106230 32876341!7560208!32876341     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32876341&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2020 ; 39 (20): e106230 Nephropedia Template TP {{tp|p=32876341|t=2020. SARS-CoV-2 targets neurons of 3D human brain organoids |pdf=|usr=}}{{32876341}} gab.com Text SARS-CoV-2 targets neurons of 3D human brain organoids JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=32876341 #FOAvip COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Dusseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19. Twit Text FOAVip SARS-CoV-2 targets neurons of 3D human brain organoids ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=32876341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32876341 #FOAvip English Wikipedia <ref>{{Cite pmid|32876341}}</ref> SARS-CoV-2 targets neurons of 3D human brain organoids #MMPMID32876341 Ramani A; Muller L; Ostermann PN; Gabriel E; Abida-Islam P; Muller-Schiffmann A; Mariappan A; Goureau O; Gruell H; Walker A; Andree M; Hauka S; Houwaart T; Dilthey A; Wohlgemuth K; Omran H; Klein F; Wieczorek D; Adams O; Timm J; Korth C; Schaal H; Gopalakrishnan J EMBO J 2020[Oct]; 39 (20): e106230 PMID32876341show ga COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Dusseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19. |Animals[MESH] |Betacoronavirus/*physiology[MESH] |Brain/*virology[MESH] |Cell Death[MESH] |Chlorocebus aethiops[MESH] |Humans[MESH] |Nervous System Diseases/virology[MESH] |Neurons/*virology[MESH] |Organoids[MESH] |SARS-CoV-2[MESH] |Vero Cells[MESH]SARS-CoV-2 targets neurons of 3D human brain organoids (epmc).pdf DeepDyve Pubget Overpricing