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10.1080/07391102.2020.1813202 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1813202 32875950!ä!32875950 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2022 ; 40 (1): 348-360 Nephropedia Template TP {{tp|p=32875950|t=2022. Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CL(pro) of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics |pdf=|usr=}}{{32875950}} gab.com Text Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CL(pro) of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32875950 #FOAvip The novel SARS-CoV-2 is the etiological agent causing the Coronavirus disease 2019 (COVID-19), which continues to become an inevitable pandemic outbreak. Over a short span of time, the structures of therapeutic target proteins for SARS-CoV-2 were identified based on the homology modelled structure of similar virus, SARS-CoV that transmitted rapidly in 2003. Since the outset of the disease, the research community has been looking for a potential drug lead. Out of all the known resolved structures related to SARS-CoV-2; 3-chymotrypsin (3 C) like protease (3CL(pro)) is considered as an attractive anti-viral drug compound on the grounds of its role in viral replication and probable non-interactive competency to bind to any viral host protein. To the best of our knowledge, till date only one compound has been identified and tested in-vitro as a potent inhibitor of 3CL(pro) protein, addressed as N3 (PubChem Compound CID: 6323191) and is known to bind irreversibly to 3CL(pro) suppressing its activity. Using computational approach, we intend to identify a probable natural fungal metabolite to interact and inhibit 3CL(pro). Here after performing docking and molecular dynamics of various small molecules derived as a secondary metabolite from fungi, we propose Flaviolin as potent inhibitor of 3CL(pro) of novel Coronavirus SARS-CoV-2.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CL(pro) of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32875950 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32875950 #FOAvip English Wikipedia <ref>{{Cite pmid|32875950}}</ref> Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CL(pro) of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics #MMPMID32875950 Rao P; Shukla A; Parmar P; Rawal RM; Patel BV; Saraf M; Goswami D J Biomol Struct Dyn 2022[Jan]; 40 (1): 348-360 PMID32875950show ga The novel SARS-CoV-2 is the etiological agent causing the Coronavirus disease 2019 (COVID-19), which continues to become an inevitable pandemic outbreak. Over a short span of time, the structures of therapeutic target proteins for SARS-CoV-2 were identified based on the homology modelled structure of similar virus, SARS-CoV that transmitted rapidly in 2003. Since the outset of the disease, the research community has been looking for a potential drug lead. Out of all the known resolved structures related to SARS-CoV-2; 3-chymotrypsin (3 C) like protease (3CL(pro)) is considered as an attractive anti-viral drug compound on the grounds of its role in viral replication and probable non-interactive competency to bind to any viral host protein. To the best of our knowledge, till date only one compound has been identified and tested in-vitro as a potent inhibitor of 3CL(pro) protein, addressed as N3 (PubChem Compound CID: 6323191) and is known to bind irreversibly to 3CL(pro) suppressing its activity. Using computational approach, we intend to identify a probable natural fungal metabolite to interact and inhibit 3CL(pro). Here after performing docking and molecular dynamics of various small molecules derived as a secondary metabolite from fungi, we propose Flaviolin as potent inhibitor of 3CL(pro) of novel Coronavirus SARS-CoV-2.Communicated by Ramaswamy H. Sarma. |*COVID-19[MESH] |*Molecular Dynamics Simulation[MESH] |Fungi[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Naphthoquinones[MESH] |Protease Inhibitors[MESH]Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3C(epmc).pdf DeepDyve Pubget Overpricing