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10.1111/sji.12967 http://scihub22266oqcxt.onion/10.1111/sji.12967 32875598!ä!32875598 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Scand+J+Immunol 2021 ; 93 (2): e12967 Nephropedia Template TP {{tp|p=32875598|t=2021. Lymphopenia an important immunological abnormality in patients with COVID-19: Possible mechanisms |pdf=|usr=}}{{32875598}} gab.com Text Lymphopenia an important immunological abnormality in patients with COVID-19: Possible mechanisms JO: Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32875598 #FOAvip The lymphopenia as a major immunological abnormality occurs in the majority of severe COVID-19 patients, which is strongly associated with mortality rate. A low proportion of lymphocytes may express the main receptor for SARS-CoV-2, called angiotensin-converting enzyme 2 (ACE2). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also use ACE2-independent pathways to enter lymphocytes. Both SARS-CoV-2- and immune-mediated mechanisms may contribute to the occurrence of lymphopenia through influencing the lymphocyte production, survival or tissue re-distribution. The metabolic and biochemical changes can also affect the production and survival of lymphocytes in COVID-19 patients. Lymphopenia can cause general immunosuppression and promote cytokine storm, both of them play an important role in the viral persistence, viral replication, multi-organ failure and eventually death. Here, a comprehensive view concerning the possible mechanisms that may lead to the lymphocyte reduction in COVID-19 patients is provided, while highlighting the potential intervention approaches to prevent lymphopenia. Twit Text FOAVip Lymphopenia an important immunological abnormality in patients with COVID-19: Possible mechanisms ????Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32875598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32875598 #FOAvip English Wikipedia <ref>{{Cite pmid|32875598}}</ref> Lymphopenia an important immunological abnormality in patients with COVID-19: Possible mechanisms #MMPMID32875598 Jafarzadeh A; Jafarzadeh S; Nozari P; Mokhtari P; Nemati M Scand J Immunol 2021[Feb]; 93 (2): e12967 PMID32875598show ga The lymphopenia as a major immunological abnormality occurs in the majority of severe COVID-19 patients, which is strongly associated with mortality rate. A low proportion of lymphocytes may express the main receptor for SARS-CoV-2, called angiotensin-converting enzyme 2 (ACE2). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also use ACE2-independent pathways to enter lymphocytes. Both SARS-CoV-2- and immune-mediated mechanisms may contribute to the occurrence of lymphopenia through influencing the lymphocyte production, survival or tissue re-distribution. The metabolic and biochemical changes can also affect the production and survival of lymphocytes in COVID-19 patients. Lymphopenia can cause general immunosuppression and promote cytokine storm, both of them play an important role in the viral persistence, viral replication, multi-organ failure and eventually death. Here, a comprehensive view concerning the possible mechanisms that may lead to the lymphocyte reduction in COVID-19 patients is provided, while highlighting the potential intervention approaches to prevent lymphopenia. |COVID-19/*immunology[MESH] |Epitopes, B-Lymphocyte/immunology[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Humans[MESH] |Lymphopenia/*immunology[MESH] |Pneumonia, Viral/immunology[MESH]Lymphopenia an important immunological abnormality in patients with CO(epmc).pdf DeepDyve Pubget Overpricing