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10.2217/nnm-2020-0286

http://scihub22266oqcxt.onion/10.2217/nnm-2020-0286
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32873192!7488724!32873192
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suck abstract from ncbi


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pmid32873192      Nanomedicine+(Lond) 2020 ; 15 (24): 2411-2427
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  • No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19 #MMPMID32873192
  • Jones GW; Monopoli MP; Campagnolo L; Pietroiusti A; Tran L; Fadeel B
  • Nanomedicine (Lond) 2020[Oct]; 15 (24): 2411-2427 PMID32873192show ga
  • There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antiviral Agents/administration & dosage/therapeutic use[MESH]
  • |Betacoronavirus/drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/metabolism/*therapy[MESH]
  • |Drug Delivery Systems/methods[MESH]
  • |Drug Repositioning/methods[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Nanomedicine/*methods[MESH]
  • |Nanoparticles/therapeutic use[MESH]
  • |Nanotechnology/methods[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/metabolism/therapeutic use[MESH]
  • |Pneumonia, Viral/drug therapy/metabolism/*therapy[MESH]


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