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10.3390/membranes10090215

http://scihub22266oqcxt.onion/10.3390/membranes10090215
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32872641!7557813!32872641
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suck abstract from ncbi


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pmid32872641      Membranes+(Basel) 2020 ; 10 (9): ä
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  • Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization #MMPMID32872641
  • Azad T; Singaravelu R; Crupi MJF; Jamieson T; Dave J; Brown EEF; Rezaei R; Taha Z; Boulton S; Martin NT; Surendran A; Poutou J; Ghahremani M; Nouri K; Whelan JT; Duong J; Tucker S; Diallo JS; Bell JC; Ilkow CS
  • Membranes (Basel) 2020[Aug]; 10 (9): ä PMID32872641show ga
  • The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic drug design strategies targeting spike trimerization. As global efforts for developing SARS-CoV-2 vaccines are rapidly underway, we believe this observation is an important consideration for identifying crucial epitopes of SARS-CoV-2.
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