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10.3390/molecules25173936 http://scihub22266oqcxt.onion/10.3390/molecules25173936 32872217!7504753!32872217     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2020 ; 25 (17): ä Nephropedia Template TP {{tp|p=32872217|t=2020. Biochemical and Computational Approach of Selected Phytocompounds from Tinospora crispa in the Management of COVID-19 |pdf=|usr=}}{{32872217}} gab.com Text Biochemical and Computational Approach of Selected Phytocompounds from Tinospora crispa in the Management of COVID-19 JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32872217 #FOAvip A pandemic caused by the novel coronavirus (SARS-CoV-2 or COVID-19) began in December 2019 in Wuhan, China, and the number of newly reported cases continues to increase. More than 19.7 million cases have been reported globally and about 728,000 have died as of this writing (10 August 2020). Recently, it has been confirmed that the SARS-CoV-2 main protease (M(pro)) enzyme is responsible not only for viral reproduction but also impedes host immune responses. The M(pro) provides a highly favorable pharmacological target for the discovery and design of inhibitors. Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. Therefore, herein, we analyzed the bioactive phytocompounds isolated by gas chromatography-mass spectroscopy (GC-MS) from Tinospora crispa as potential COVID-19 M(pro) inhibitors, using molecular docking study. Our analyses unveiled that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules, with three of them exerting biological activity and warranting further optimization and drug development to combat COVID-19. Twit Text FOAVip Biochemical and Computational Approach of Selected Phytocompounds from Tinospora crispa in the Management of COVID-19 ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32872217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32872217 #FOAvip English Wikipedia <ref>{{Cite pmid|32872217}}</ref> Biochemical and Computational Approach of Selected Phytocompounds from Tinospora crispa in the Management of COVID-19 #MMPMID32872217 Rakib A; Paul A; Chy MNU; Sami SA; Baral SK; Majumder M; Tareq AM; Amin MN; Shahriar A; Uddin MZ; Dutta M; Tallei TE; Emran TB; Simal-Gandara J Molecules 2020[Aug]; 25 (17): ä PMID32872217show ga A pandemic caused by the novel coronavirus (SARS-CoV-2 or COVID-19) began in December 2019 in Wuhan, China, and the number of newly reported cases continues to increase. More than 19.7 million cases have been reported globally and about 728,000 have died as of this writing (10 August 2020). Recently, it has been confirmed that the SARS-CoV-2 main protease (M(pro)) enzyme is responsible not only for viral reproduction but also impedes host immune responses. The M(pro) provides a highly favorable pharmacological target for the discovery and design of inhibitors. Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. Therefore, herein, we analyzed the bioactive phytocompounds isolated by gas chromatography-mass spectroscopy (GC-MS) from Tinospora crispa as potential COVID-19 M(pro) inhibitors, using molecular docking study. Our analyses unveiled that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules, with three of them exerting biological activity and warranting further optimization and drug development to combat COVID-19. |Antiviral Agents/*chemistry/classification/isolation & purification/pharmacology[MESH] |Betacoronavirus/*chemistry/drug effects/enzymology[MESH] |COVID-19[MESH] |Catalytic Domain[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/drug therapy[MESH] |Cysteine Endopeptidases/chemistry/genetics/metabolism[MESH] |Drug Discovery[MESH] |Gas Chromatography-Mass Spectrometry[MESH] |Gene Expression[MESH] |Humans[MESH] |Kinetics[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Phytochemicals/*chemistry/classification/isolation & purification/pharmacology[MESH] |Pneumonia, Viral/drug therapy[MESH] |Protease Inhibitors/*chemistry/classification/isolation & purification/pharmacology[MESH] |Protein Binding[MESH] |Protein Interaction Domains and Motifs[MESH] |Protein Structure, Secondary[MESH] |SARS-CoV-2[MESH] |Substrate Specificity[MESH] |Thermodynamics[MESH] |Tinospora/*chemistry[MESH]Biochemical and Computational Approach of Selected Phytocompounds from(epmc).pdf DeepDyve Pubget Overpricing