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10.21873/invivo.12138

http://scihub22266oqcxt.onion/10.21873/invivo.12138
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32871850!7652506!32871850
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suck abstract from ncbi


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pmid32871850      In+Vivo 2020 ; 34 (5): 3039-3045
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  • Preliminary Data of a Quantitative Point of Care Test for SARS-CoV-2 Antibodies From Greece #MMPMID32871850
  • Fragkou PC; Papaevangelou V; Antoniadou A; Kavvatha D; Ploussi A; Pantazis N; Sirmpilantze T; Psarrakis C; Pournaras SA; Tsiodras S; Kelekis A
  • In Vivo 2020[Sep]; 34 (5): 3039-3045 PMID32871850show ga
  • BACKGROUND: Antibody testing is necessary to identify immune individuals in the post-initial wave of the COVID-19 pandemic. PATIENTS AND METHODS: We prospectively evaluated the performance of a quantitative point-of-care test (POCT) for SARS-CoV-2 antibodies. The patient group (PG) comprised of hospitalized confirmed COVID-19 cases. Asymptomatic healthcare volunteers with negative rRT-PCR were included in the control group (CG). Measurement of IgM and IgG was obtained by dry fluorescence immunoassay. RESULTS: Twenty-six PG (65.9+/-15.4 years old, male 57.7%) and 18 CG (45.6+/-10.1 years old, male 33.3%) were included. By manufacturer's cut-off (>/=0.04 mIU/ml), sensitivity and specificity were 73.08% and 88.89% for IgM and 88.46% and 33.33% for IgG, respectively. Estimated areas under the ROC curve were 0.907 and 0.848 for IgM and IgG, respectively. Results were improved using a cut-off of IgM >/=0.05 mIU/ml and IgG >/=0.10 mIU/ml. CONCLUSION: Using stringent cut-off values, SARS-CoV-2 antibody POCT detects immune people and can be used during socioeconomic normalization of communities.
  • |*Pandemics[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/blood/*isolation & purification[MESH]
  • |Betacoronavirus/*isolation & purification/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/epidemiology/virology[MESH]
  • |Greece/epidemiology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/isolation & purification[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia, Viral/*diagnosis/epidemiology/virology[MESH]
  • |Point-of-Care Systems[MESH]
  • |SARS-CoV-2[MESH]


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