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10.21873/invivo.12135

http://scihub22266oqcxt.onion/10.21873/invivo.12135
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32871847!7652447!32871847
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suck abstract from ncbi


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pmid32871847      In+Vivo 2020 ; 34 (5): 3027-3028
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  • Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality #MMPMID32871847
  • Smetana K Jr; Rosel D; BrAbek J
  • In Vivo 2020[Sep]; 34 (5): 3027-3028 PMID32871847show ga
  • The FDA-approved drugs raloxifene and bazedoxifene could be among the best candidates to prevent mortality in severe COVID-19 patients. Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. In addition, raloxifene and bazedoxifene are selective estrogen receptor modulators with strong antiviral activity.
  • |Betacoronavirus/drug effects/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/genetics/mortality/virology[MESH]
  • |Cytokines/antagonists & inhibitors/genetics[MESH]
  • |Humans[MESH]
  • |Indoles/*pharmacology[MESH]
  • |Interleukin-6/antagonists & inhibitors/genetics[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/genetics/mortality/virology[MESH]
  • |Raloxifene Hydrochloride/*pharmacology[MESH]
  • |Receptors, Estrogen/antagonists & inhibitors[MESH]
  • |Respiratory Distress Syndrome/*drug therapy/prevention & control/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Selective Estrogen Receptor Modulators/pharmacology[MESH]


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