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10.1016/j.lfs.2020.118355 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118355 32871183!7456265!32871183     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2020 ; 261 (ä): 118355 Nephropedia Template TP {{tp|p=32871183|t=2020. Immunocytometric analysis of COVID patients: A contribution to personalized therapy?|pdf=|usr=}}{{32871183}} gab.com Text Immunocytometric analysis of COVID patients: A contribution to personalized therapy JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32871183 #FOAvip AIMS: This study aims to cast light on immunocytometric alterations in COVID-19, a potentially fatal viral infection with heterogeneous clinical expression and a not completely defined pathophysiology. METHODS: We studied 35 COVID patients at hospital admission testing by cytofluorimetry a large panel of lymphocyte subpopulations and serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-17A and the soluble receptor of IL-17A (IL-17RA). KEY FINDINGS: At hospital admission, total lymphocytes and most T and B subpopulations were reduced in 50-80% of patients, with close relationship to disease severity. While activated T helper 1 (TH1) and TH17 cells resulted normal or higher. Serum IL-6 was increased in all patients, while TNF-alpha and IL-17A were higher in advanced stages. A patient subset with low severity had very high IL-17RA levels. Tocilizumab treatment caused an increase of IL-17A in 3/6 patients and a reduction in 3 others, while the lymphocyte number increased in 3 patients and did not change in the others. SIGNIFICANCE: Cytofluorimetry revealed a functional exhaustion of most lymphocyte populations in COVID patients not involving activated TH1 and TH17. Consequently, there was a relevant cytokines production that contributes to impair the respiratory inflammation. The increase of TH17 and IL-17 in a subset of cases and the evidence of a significant increase of IL-17RA (that prevents the interaction of IL-17 with the cell receptor) in patients with low severity suggest that some patients could benefit from monoclonal antibodies treatment targeting IL-17 pathway. Immunocytofluorimetric markers may contribute to a personalized therapy in COVID patients. Twit Text FOAVip Immunocytometric analysis of COVID patients: A contribution to personalized therapy ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32871183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32871183 #FOAvip English Wikipedia <ref>{{Cite pmid|32871183}}</ref> Immunocytometric analysis of COVID patients: A contribution to personalized therapy? #MMPMID32871183 Cacciapuoti S; De Rosa A; Gelzo M; Megna M; Raia M; Pinchera B; Pontarelli A; Scotto R; Scala E; Scarano F; Scalia G; Castaldo G; Fabbrocini G; Gentile I; Parrella R Life Sci 2020[Nov]; 261 (ä): 118355 PMID32871183show ga AIMS: This study aims to cast light on immunocytometric alterations in COVID-19, a potentially fatal viral infection with heterogeneous clinical expression and a not completely defined pathophysiology. METHODS: We studied 35 COVID patients at hospital admission testing by cytofluorimetry a large panel of lymphocyte subpopulations and serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-17A and the soluble receptor of IL-17A (IL-17RA). KEY FINDINGS: At hospital admission, total lymphocytes and most T and B subpopulations were reduced in 50-80% of patients, with close relationship to disease severity. While activated T helper 1 (TH1) and TH17 cells resulted normal or higher. Serum IL-6 was increased in all patients, while TNF-alpha and IL-17A were higher in advanced stages. A patient subset with low severity had very high IL-17RA levels. Tocilizumab treatment caused an increase of IL-17A in 3/6 patients and a reduction in 3 others, while the lymphocyte number increased in 3 patients and did not change in the others. SIGNIFICANCE: Cytofluorimetry revealed a functional exhaustion of most lymphocyte populations in COVID patients not involving activated TH1 and TH17. Consequently, there was a relevant cytokines production that contributes to impair the respiratory inflammation. The increase of TH17 and IL-17 in a subset of cases and the evidence of a significant increase of IL-17RA (that prevents the interaction of IL-17 with the cell receptor) in patients with low severity suggest that some patients could benefit from monoclonal antibodies treatment targeting IL-17 pathway. Immunocytofluorimetric markers may contribute to a personalized therapy in COVID patients. |Aged[MESH] |Antibodies, Monoclonal, Humanized/administration & dosage/pharmacology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/physiopathology/virology[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Flow Cytometry/*methods[MESH] |Humans[MESH] |Inflammation/immunology/virology[MESH] |Lymphocyte Count[MESH] |Lymphocyte Subsets/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Patient Admission[MESH] |Pneumonia, Viral/*immunology/physiopathology/virology[MESH] |Precision Medicine[MESH] |Prospective Studies[MESH]Immunocytometric analysis of COVID patients: A contribution to persona(epmc).pdf DeepDyve Pubget Overpricing