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10.1007/s00415-020-10197-8 http://scihub22266oqcxt.onion/10.1007/s00415-020-10197-8 32870373!7461160!32870373     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32870373&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Neurol 2021 ; 268 (6): 2013-2022 Nephropedia Template TP {{tp|p=32870373|t=2021. Why do SARS-CoV-2 NSPs rush to the ER?|pdf=|usr=}}{{32870373}} gab.com Text Why do SARS-CoV-2 NSPs rush to the ER JO: J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=32870373 #FOAvip SARS-CoV-2, which led to the 2020 global pandemic, is responsible for the Coronavirus Disease 2019 (COVID-19), a respiratory illness, and presents a tropism for the central nervous system. Like most members of this family, the virus is composed of structural and non-structural proteins (NSPs). The non-structural proteins are critical elements of the replication and transcription complex (RTC), as well as immune system evasion. Through hijacking the endoplasmic reticulum (ER) membrane, NSPs help the virus establish the RTC, inducing ER stress after membrane rearrangement and causing severe neuronal disturbance. In this review, we focus on the role of Nsp3, 4, and 6 in intracellular membrane rearrangement and evaluate the potential disruption of the central nervous system and the neurodegeneration which it could trigger. Studies of these NSPs will not only bring to light their specific role in viral infection but also facilitate the discovery of novel targeted drugs. Twit Text FOAVip Why do SARS-CoV-2 NSPs rush to the ER ????J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=32870373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32870373 #FOAvip English Wikipedia <ref>{{Cite pmid|32870373}}</ref> Why do SARS-CoV-2 NSPs rush to the ER? #MMPMID32870373 Santerre M; Arjona SP; Allen CN; Shcherbik N; Sawaya BE J Neurol 2021[Jun]; 268 (6): 2013-2022 PMID32870373show ga SARS-CoV-2, which led to the 2020 global pandemic, is responsible for the Coronavirus Disease 2019 (COVID-19), a respiratory illness, and presents a tropism for the central nervous system. Like most members of this family, the virus is composed of structural and non-structural proteins (NSPs). The non-structural proteins are critical elements of the replication and transcription complex (RTC), as well as immune system evasion. Through hijacking the endoplasmic reticulum (ER) membrane, NSPs help the virus establish the RTC, inducing ER stress after membrane rearrangement and causing severe neuronal disturbance. In this review, we focus on the role of Nsp3, 4, and 6 in intracellular membrane rearrangement and evaluate the potential disruption of the central nervous system and the neurodegeneration which it could trigger. Studies of these NSPs will not only bring to light their specific role in viral infection but also facilitate the discovery of novel targeted drugs. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Pandemics[MESH] |Proteins[MESH]Why do SARS-CoV-2 NSPs rush to the ER?(epmc).pdf DeepDyve Pubget Overpricing