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10.1111/jcmm.15812 http://scihub22266oqcxt.onion/10.1111/jcmm.15812 32869923!7579697!32869923     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2020 ; 24 (20): 11922-11935 Nephropedia Template TP {{tp|p=32869923|t=2020. A biflavonoid-rich extract from Selaginella moellendorffii Hieron induces apoptosis via STAT3 and Akt/NF-kappaB signalling pathways in laryngeal carcinoma |pdf=|usr=}}{{32869923}} gab.com Text A biflavonoid-rich extract from Selaginella moellendorffii Hieron induces apoptosis via STAT3 and Akt/NF-kappaB signalling pathways in laryngeal carcinoma JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32869923 #FOAvip Selaginella moellendorffii Hieron. (SM), a perennial evergreen plant, has been used in the treatment of acute infectious hepatitis, thoracic and hypochondriac lumbar contusions, systemic oedema and thrombocytopaenia. However, the role of a biflavonoid-rich extract from SM (SM-BFRE) in anti-larynx cancer has rarely been reported. In this study, the in vitro and in vivo anti-laryngeal cancer activity and potential mechanisms of SM-BFRE were investigated. An off-line semipreparative liquid chromatography-nuclear magnetic resonance protocol was carried out to determine six biflavonoids from SM-BFRE. In vitro, MTT assay revealed that SM-BFRE inhibited the proliferation of laryngeal carcinoma cells. A wound healing assay indicated that SM-BFRE suppressed the migration of laryngeal cancer cells. Hoechst 33 258 and Annexin V-FITC/PI double staining assays were performed and verified that SM-BFRE induced apoptosis in laryngeal carcinoma cells. The Hep-2 bearing nude mouse model confirmed that SM-BFRE also exhibited anticancer effect in vivo. In addition, Western blot analysis demonstrated that SM-BFRE exerted its anti-laryngeal cancer effect by activating the mitochondrial apoptotic pathway and inhibiting STAT3 and Akt/NF-kappaB signalling pathways. All results suggested that SM-BFRE could be considered as a potential chemotherapeutic drug for laryngeal cancer. Twit Text FOAVip A biflavonoid-rich extract from Selaginella moellendorffii Hieron induces apoptosis via STAT3 and Akt/NF-kappaB signalling pathways in laryngeal carcinoma ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32869923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32869923 #FOAvip English Wikipedia <ref>{{Cite pmid|32869923}}</ref> A biflavonoid-rich extract from Selaginella moellendorffii Hieron induces apoptosis via STAT3 and Akt/NF-kappaB signalling pathways in laryngeal carcinoma #MMPMID32869923 Huang H; Hao J; Pang K; Lv Y; Wan D; Wu C; Ma Y; Yang X; Zhang WK J Cell Mol Med 2020[Oct]; 24 (20): 11922-11935 PMID32869923show ga Selaginella moellendorffii Hieron. (SM), a perennial evergreen plant, has been used in the treatment of acute infectious hepatitis, thoracic and hypochondriac lumbar contusions, systemic oedema and thrombocytopaenia. However, the role of a biflavonoid-rich extract from SM (SM-BFRE) in anti-larynx cancer has rarely been reported. In this study, the in vitro and in vivo anti-laryngeal cancer activity and potential mechanisms of SM-BFRE were investigated. An off-line semipreparative liquid chromatography-nuclear magnetic resonance protocol was carried out to determine six biflavonoids from SM-BFRE. In vitro, MTT assay revealed that SM-BFRE inhibited the proliferation of laryngeal carcinoma cells. A wound healing assay indicated that SM-BFRE suppressed the migration of laryngeal cancer cells. Hoechst 33 258 and Annexin V-FITC/PI double staining assays were performed and verified that SM-BFRE induced apoptosis in laryngeal carcinoma cells. The Hep-2 bearing nude mouse model confirmed that SM-BFRE also exhibited anticancer effect in vivo. In addition, Western blot analysis demonstrated that SM-BFRE exerted its anti-laryngeal cancer effect by activating the mitochondrial apoptotic pathway and inhibiting STAT3 and Akt/NF-kappaB signalling pathways. All results suggested that SM-BFRE could be considered as a potential chemotherapeutic drug for laryngeal cancer. |Animals[MESH] |Apoptosis/*drug effects[MESH] |Biflavonoids/chemistry/*pharmacology[MESH] |Cell Line, Tumor[MESH] |Cell Movement/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Female[MESH] |Humans[MESH] |Laryngeal Neoplasms/*metabolism/*pathology[MESH] |Mice, Inbred BALB C[MESH] |Mice, Nude[MESH] |Models, Biological[MESH] |NF-kappa B/*metabolism[MESH] |Neoplasm Transplantation[MESH] |Plant Extracts/chemistry/*pharmacology[MESH] |Proto-Oncogene Proteins c-akt/metabolism[MESH] |STAT3 Transcription Factor/*metabolism[MESH] |Selaginellaceae/*chemistry[MESH]A biflavonoid-rich extract from Selaginella moellendorffii Hieron ind(epmc).pdf DeepDyve Pubget Overpricing