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10.1128/AAC.01521-20

http://scihub22266oqcxt.onion/10.1128/AAC.01521-20
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32868327!7577145!32868327
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suck abstract from ncbi


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pmid32868327      Antimicrob+Agents+Chemother 2020 ; 64 (11): ä
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  • Removal of Remdesivir s Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19 #MMPMID32868327
  • Le MP; Le Hingrat Q; Jaquet P; Wicky PH; Bunel V; Massias L; Visseaux B; Messika J; Descamps D; Mal H; Timsit JF; Peytavin G
  • Antimicrob Agents Chemother 2020[Oct]; 64 (11): ä PMID32868327show ga
  • Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU) settings, in which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining remdesivir treatment, while improving tolerance, by removing both remdesivir's metabolite (GS-441524) and sulfobutylether beta-cyclodextrin sodium (SEBCD). Additional studies may prove informative, particularly in the evaluations of therapeutic options for coronavirus disease 2019 (COVID-19).
  • |Adenosine Monophosphate/administration & dosage/adverse effects/*analogs & derivatives/chemistry/metabolism[MESH]
  • |Adenosine/analogs & derivatives[MESH]
  • |Alanine/administration & dosage/adverse effects/*analogs & derivatives/chemistry/metabolism[MESH]
  • |Antiviral Agents/*administration & dosage/adverse effects/chemistry/metabolism[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/drug therapy/surgery/*therapy/virology[MESH]
  • |Drug Interactions[MESH]
  • |Furans/adverse effects/chemistry/*urine[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Lung Transplantation[MESH]
  • |Multiple Organ Failure[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/surgery/*therapy/virology[MESH]
  • |Pyrroles/adverse effects/chemistry/*urine[MESH]
  • |Renal Dialysis[MESH]
  • |SARS-CoV-2[MESH]
  • |Transplant Recipients[MESH]
  • |Triazines/adverse effects/chemistry/*urine[MESH]


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