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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Antimicrob+Agents+Chemother 2020 ; 64 (11): ä Nephropedia Template TP
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Removal of Remdesivir s Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19 #MMPMID32868327
Le MP; Le Hingrat Q; Jaquet P; Wicky PH; Bunel V; Massias L; Visseaux B; Messika J; Descamps D; Mal H; Timsit JF; Peytavin G
Antimicrob Agents Chemother 2020[Oct]; 64 (11): ä PMID32868327show ga
Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU) settings, in which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining remdesivir treatment, while improving tolerance, by removing both remdesivir's metabolite (GS-441524) and sulfobutylether beta-cyclodextrin sodium (SEBCD). Additional studies may prove informative, particularly in the evaluations of therapeutic options for coronavirus disease 2019 (COVID-19).