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10.3390/ijms21176204 http://scihub22266oqcxt.onion/10.3390/ijms21176204 32867310!7503761!32867310     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (17): ä Nephropedia Template TP {{tp|p=32867310|t=2020. The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury |pdf=|usr=}}{{32867310}} gab.com Text The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32867310 #FOAvip Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a secondary phase in which neuroinflammation plays a key role. NLRP3 inflammasome is a component of the innate immune response and different diseases, such as neurodegenerative diseases, are characterized by NLRP3 activation. This review aims to describe NLRP3 inflammasome and the consequences related to its activation following TBI. NLRP3, caspase-1, IL-1beta, and IL-18 are significantly upregulated after TBI, therefore, the use of nonspecific, but mostly specific NLRP3 inhibitors is useful to ameliorate the damage post-TBI characterized by neuroinflammation. Moreover, NLRP3 and the molecules associated with its activation may be considered as biomarkers and predictive factors for other neurodegenerative diseases consequent to TBI. Complications such as continuous stimuli or viral infections, such as the SARS-CoV-2 infection, may worsen the prognosis of TBI, altering the immune response and increasing the neuroinflammatory processes related to NLRP3, whose activation occurs both in TBI and in SARS-CoV-2 infection. This review points out the role of NLRP3 in TBI and highlights the hypothesis that NLRP3 may be considered as a potential therapeutic target for the management of neuroinflammation in TBI. Twit Text FOAVip The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32867310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32867310 #FOAvip English Wikipedia <ref>{{Cite pmid|32867310}}</ref> The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury #MMPMID32867310 Irrera N; Russo M; Pallio G; Bitto A; Mannino F; Minutoli L; Altavilla D; Squadrito F Int J Mol Sci 2020[Aug]; 21 (17): ä PMID32867310show ga Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a secondary phase in which neuroinflammation plays a key role. NLRP3 inflammasome is a component of the innate immune response and different diseases, such as neurodegenerative diseases, are characterized by NLRP3 activation. This review aims to describe NLRP3 inflammasome and the consequences related to its activation following TBI. NLRP3, caspase-1, IL-1beta, and IL-18 are significantly upregulated after TBI, therefore, the use of nonspecific, but mostly specific NLRP3 inhibitors is useful to ameliorate the damage post-TBI characterized by neuroinflammation. Moreover, NLRP3 and the molecules associated with its activation may be considered as biomarkers and predictive factors for other neurodegenerative diseases consequent to TBI. Complications such as continuous stimuli or viral infections, such as the SARS-CoV-2 infection, may worsen the prognosis of TBI, altering the immune response and increasing the neuroinflammatory processes related to NLRP3, whose activation occurs both in TBI and in SARS-CoV-2 infection. This review points out the role of NLRP3 in TBI and highlights the hypothesis that NLRP3 may be considered as a potential therapeutic target for the management of neuroinflammation in TBI. |*Inflammasomes[MESH] |Betacoronavirus/*immunology[MESH] |Biomarkers/metabolism[MESH] |Brain Injuries, Traumatic/diagnosis/drug therapy/*physiopathology[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications[MESH] |Humans[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors/genetics/*metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications[MESH] |Prognosis[MESH] |Pyroptosis[MESH]The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain (epmc).pdf DeepDyve Pubget Overpricing