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10.3390/genes11091010 http://scihub22266oqcxt.onion/10.3390/genes11091010 32867305!7565048!32867305     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2020 ; 11 (9): ä Nephropedia Template TP {{tp|p=32867305|t=2020. COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells |pdf=|usr=}}{{32867305}} gab.com Text COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32867305 #FOAvip The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene, we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID-19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS-CoV-2. These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity. Twit Text FOAVip COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32867305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32867305 #FOAvip English Wikipedia <ref>{{Cite pmid|32867305}}</ref> COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells #MMPMID32867305 Latini A; Agolini E; Novelli A; Borgiani P; Giannini R; Gravina P; Smarrazzo A; Dauri M; Andreoni M; Rogliani P; Bernardini S; Helmer-Citterich M; Biancolella M; Novelli G Genes (Basel) 2020[Aug]; 11 (9): ä PMID32867305show ga The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene, we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID-19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS-CoV-2. These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity. |*Mutation[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Basigin/*genetics[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Coronavirus Infections/*genetics/pathology[MESH] |Dipeptidyl Peptidase 4/genetics[MESH] |Exome[MESH] |Female[MESH] |Furin/*genetics[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*genetics/pathology[MESH] |Polymorphism, Single Nucleotide[MESH]COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 En(epmc).pdf DeepDyve Pubget Overpricing