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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Immunol 2020 ; 220 (ä): 108576 Nephropedia Template TP
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Interferon gamma, TGF-beta1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients #MMPMID32866645
Montalvo Villalba MC; Valdes Ramirez O; Mune Jimenez M; Arencibia Garcia A; Martinez Alfonso J; Gonzalez Baez G; Roque Arrieta R; Rosell Simon D; Alvarez Gainza D; Sierra Vazquez B; Resik Aguirre S; Guzman Tirado MG
Clin Immunol 2020[Nov]; 220 (ä): 108576 PMID32866645show ga
Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-gamma, TGF-beta1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-gamma expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0.0393). IFN-gamma expression was increased in symptomatic patients (p = 0.0405). TGF-beta1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0.0001; p = 0.0011, respectively). A significant correlation between IFN-gamma and TGF-beta1 was observed in SARS-CoV-2 asymptomatic patients (r = +0.61, p = 0.0014). The findings suggest that imbalance between IFN-gamma and TGF-beta1 expression could be an impact in clinical expression of SARS-CoV-2 infection.