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10.1016/j.clim.2020.108576

http://scihub22266oqcxt.onion/10.1016/j.clim.2020.108576
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suck abstract from ncbi


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pmid32866645      Clin+Immunol 2020 ; 220 (ä): 108576
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  • Interferon gamma, TGF-beta1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients #MMPMID32866645
  • Montalvo Villalba MC; Valdes Ramirez O; Mune Jimenez M; Arencibia Garcia A; Martinez Alfonso J; Gonzalez Baez G; Roque Arrieta R; Rosell Simon D; Alvarez Gainza D; Sierra Vazquez B; Resik Aguirre S; Guzman Tirado MG
  • Clin Immunol 2020[Nov]; 220 (ä): 108576 PMID32866645show ga
  • Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-gamma, TGF-beta1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-gamma expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0.0393). IFN-gamma expression was increased in symptomatic patients (p = 0.0405). TGF-beta1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0.0001; p = 0.0011, respectively). A significant correlation between IFN-gamma and TGF-beta1 was observed in SARS-CoV-2 asymptomatic patients (r = +0.61, p = 0.0014). The findings suggest that imbalance between IFN-gamma and TGF-beta1 expression could be an impact in clinical expression of SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Asymptomatic Diseases[MESH]
  • |Betacoronavirus/immunology/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Chemokine CCL5/*genetics/immunology[MESH]
  • |Coronavirus Infections/diagnosis/*immunology/pathology/virology[MESH]
  • |Female[MESH]
  • |Gene Expression[MESH]
  • |Host-Pathogen Interactions/genetics/immunology[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/*genetics/immunology[MESH]
  • |Lung/immunology/pathology/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/immunology/pathology/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*immunology/pathology/virology[MESH]
  • |RNA, Messenger/*genetics/immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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