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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Braz+J+Infect+Dis 2020 ; 24 (5): 428-433 Nephropedia Template TP
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Immune response in SARS-CoV-2 infection: the role of interferons type I and type III #MMPMID32866437
Portela Sousa C; Brites C
Braz J Infect Dis 2020[Sep]; 24 (5): 428-433 PMID32866437show ga
BACKGROUND: There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. OBJECTIVE: To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. METHODS: We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. RESULTS: The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19. CONCLUSIONS: Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19.