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The phenotypic changes of gammadelta T cells in COVID-19 patients #MMPMID32864865
Lei L; Qian H; Yang X; Zhang X; Zhang D; Dai T; Guo R; Shi L; Cheng Y; Zhang B; Zhou X; Hu J; Guo Y
J Cell Mol Med 2020[Oct]; 24 (19): 11603-11606 PMID32864865show ga
A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2?broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on gammadelta T cell population. In comparison with HD, the gammadelta T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in gammadelta T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.