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10.1111/jcmm.15620

http://scihub22266oqcxt.onion/10.1111/jcmm.15620
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32864865!7576249!32864865
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suck abstract from ncbi


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pmid32864865      J+Cell+Mol+Med 2020 ; 24 (19): 11603-11606
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  • The phenotypic changes of gammadelta T cells in COVID-19 patients #MMPMID32864865
  • Lei L; Qian H; Yang X; Zhang X; Zhang D; Dai T; Guo R; Shi L; Cheng Y; Zhang B; Zhou X; Hu J; Guo Y
  • J Cell Mol Med 2020[Oct]; 24 (19): 11603-11606 PMID32864865show ga
  • A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2?broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on gammadelta T cell population. In comparison with HD, the gammadelta T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in gammadelta T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Betacoronavirus/physiology[MESH]
  • |Biomarkers[MESH]
  • |CD4 Antigens/metabolism[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Flow Cytometry[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Interleukin-2 Receptor alpha Subunit/metabolism[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]
  • |SARS-CoV-2[MESH]


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