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10.1007/s40495-020-00231-8 http://scihub22266oqcxt.onion/10.1007/s40495-020-00231-8 32864299!7443392!32864299     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Pharmacol+Rep 2020 ; 6 (5): 203-211 Nephropedia Template TP {{tp|p=32864299|t=2020. Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2 |pdf=|usr=}}{{32864299}} gab.com Text Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2 JO: Curr Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32864299 #FOAvip PURPOSE OF REVIEW: The rapid spread of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has turned out to be a global emergency. Symptoms of this viral infection, coronavirus disease 2019 (COVID-19), include mild infections of the upper respiratory tract, viral pneumonia, respiratory failure, multiple organ failure and death. Till date, no drugs have been discovered to treat COVID-19 patients, and therefore, a considerable amount of interest has been shown in repurposing the existing drugs. RECENT FINDINGS: Out of these drugs, chloroquine (CQ) and hydroxychloroquine (HCQ) have demonstrated positive results indicating a potential antiviral role against SARS-CoV-2. Its mechanism of action (MOA) includes the interference in the endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site and prevention of cytokine storm. Unfortunately, its adverse effects like gastrointestinal complications, retinopathy and QT interval prolongation are evident in treated COVID-19 patients. Yet, multiple clinical trials have been employed in several countries to evaluate its ability in turning into a needed drug in this pandemic. SUMMARY: This review attempts to summarize the MOA of CQ/HCQ and its side effects. The existing literature hints that till date, the role of CQ/HCQ in COVID-19 may be sceptical, and further studies are warranted for obtaining a therapeutic option that could be effectively used across the world to rise out from this pandemic. Twit Text FOAVip Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2 ????Curr Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32864299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32864299 #FOAvip English Wikipedia <ref>{{Cite pmid|32864299}}</ref> Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2 #MMPMID32864299 Satarker S; Ahuja T; Banerjee M; E VB; Dogra S; Agarwal T; Nampoothiri M Curr Pharmacol Rep 2020[]; 6 (5): 203-211 PMID32864299show ga PURPOSE OF REVIEW: The rapid spread of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has turned out to be a global emergency. Symptoms of this viral infection, coronavirus disease 2019 (COVID-19), include mild infections of the upper respiratory tract, viral pneumonia, respiratory failure, multiple organ failure and death. Till date, no drugs have been discovered to treat COVID-19 patients, and therefore, a considerable amount of interest has been shown in repurposing the existing drugs. RECENT FINDINGS: Out of these drugs, chloroquine (CQ) and hydroxychloroquine (HCQ) have demonstrated positive results indicating a potential antiviral role against SARS-CoV-2. Its mechanism of action (MOA) includes the interference in the endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the angiotensin-converting enzyme 2 (ACE2) binding site and prevention of cytokine storm. Unfortunately, its adverse effects like gastrointestinal complications, retinopathy and QT interval prolongation are evident in treated COVID-19 patients. Yet, multiple clinical trials have been employed in several countries to evaluate its ability in turning into a needed drug in this pandemic. SUMMARY: This review attempts to summarize the MOA of CQ/HCQ and its side effects. The existing literature hints that till date, the role of CQ/HCQ in COVID-19 may be sceptical, and further studies are warranted for obtaining a therapeutic option that could be effectively used across the world to rise out from this pandemic. äHydroxychloroquine in COVID-19: Potential Mechanism of Action Against (epmc).pdf DeepDyve Pubget Overpricing