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10.7861/clinmed.2020-0351 http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0351 32863274!7687307!32863274     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Med+(Lond) 2020 ; 20 (6): e218-e221 Nephropedia Template TP {{tp|p=32863274|t=2020. Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19 |pdf=|usr=}}{{32863274}} gab.com Text Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19 JO: Clin Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=32863274 #FOAvip Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical agent with an excellent history of clinical use, namely heparin. Heparin is best known as an anticoagulant, but it also exhibits direct antiviral activity against many enveloped viruses and has anti-inflammatory activity. The high incidence of thromboembolic events in COVID-19 patients suggests that coagulopathy plays an important role in the SARS-CoV-2 pathogenesis. This already makes heparin a unique, potentially curative agent that can be used immediately to help resolve the ongoing crisis associated with SARS-CoV-2 infection and COVID-19 disease. We demonstrate here in vitro that heparin does indeed inhibit SARS-CoV-2 infection. The three concurrent modes of activity of heparin (antiviral, anticoagulant and anti-inflammatory) against SARS-CoV-2/COVID-19 form a unique therapeutic combination. Thus, repurposing of heparin to fight SARS-CoV-2 and COVID-19 appears to be a powerful, readily available measure to address the current pandemic. Twit Text FOAVip Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19 ????Clin Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=32863274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32863274 #FOAvip English Wikipedia <ref>{{Cite pmid|32863274}}</ref> Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19 #MMPMID32863274 Conzelmann C; Muller JA; Perkhofer L; Sparrer KM; Zelikin AN; Munch J; Kleger A Clin Med (Lond) 2020[Nov]; 20 (6): e218-e221 PMID32863274show ga Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical agent with an excellent history of clinical use, namely heparin. Heparin is best known as an anticoagulant, but it also exhibits direct antiviral activity against many enveloped viruses and has anti-inflammatory activity. The high incidence of thromboembolic events in COVID-19 patients suggests that coagulopathy plays an important role in the SARS-CoV-2 pathogenesis. This already makes heparin a unique, potentially curative agent that can be used immediately to help resolve the ongoing crisis associated with SARS-CoV-2 infection and COVID-19 disease. We demonstrate here in vitro that heparin does indeed inhibit SARS-CoV-2 infection. The three concurrent modes of activity of heparin (antiviral, anticoagulant and anti-inflammatory) against SARS-CoV-2/COVID-19 form a unique therapeutic combination. Thus, repurposing of heparin to fight SARS-CoV-2 and COVID-19 appears to be a powerful, readily available measure to address the current pandemic. |Administration, Inhalation[MESH] |Anti-Inflammatory Agents/*therapeutic use[MESH] |Anticoagulants/*therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drug Repositioning[MESH] |Heparin/*therapeutic use[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH]Inhaled and systemic heparin as a repurposed direct antiviral drug for(epmc).pdf DeepDyve Pubget Overpricing