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10.7861/clinmed.2020-0524

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0524
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32863273!7687338!32863273
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suck abstract from ncbi


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pmid32863273      Clin+Med+(Lond) 2020 ; 20 (6): e215-e217
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  • Antiviral treatment for COVID-19: the evidence supporting remdesivir #MMPMID32863273
  • Richardson C; Bhagani S; Pollara G
  • Clin Med (Lond) 2020[Nov]; 20 (6): e215-e217 PMID32863273show ga
  • The emergence of the novel beta coronavirus SARS-CoV-2 and the ensuing COVID-19 pandemic has generated a rapidly evolving research landscape in the search for new therapeutic agents. The intravenous antiviral drug remdesivir has in vitro activity against SARS-CoV-2 and now studies have reported its clinical efficacy, demonstrating shorter time to recovery in hospitalised patients with severe COVID-19. Adverse event rates were low and remdesivir has now received conditional marketing authorisation from the European Medicines Agency. An interim clinical commissioning policy is in place in the UK. These studies make remdesivir the first antiviral drug able to alter the natural history of severe COVID-19, and a benchmark for the comparison of new therapies in the future. Ongoing studies are investigating its use in early mild/moderate COVID-19, alternative formulations, and the combination of remdesivir with immunomodulatory agents.
  • |*Antiviral Agents/administration & dosage/adverse effects/therapeutic use[MESH]
  • |Adenosine Monophosphate/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use[MESH]
  • |Administration, Intravenous[MESH]
  • |Alanine/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Randomized Controlled Trials as Topic[MESH]


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