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10.1016/j.acvd.2020.07.001

http://scihub22266oqcxt.onion/10.1016/j.acvd.2020.07.001
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32863157!7430243!32863157
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suck abstract from ncbi

pmid32863157      Arch+Cardiovasc+Dis 2020 ; 113 (8-9): 572-578
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  • Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2 #MMPMID32863157
  • Levy BI; Fauvel JP
  • Arch Cardiovasc Dis 2020[Aug]; 113 (8-9): 572-578 PMID32863157show ga
  • Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.
  • |*Betacoronavirus[MESH]
  • |*Pandemics[MESH]
  • |Angiotensin II Type 1 Receptor Blockers/*therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology/metabolism[MESH]
  • |Humans[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology/metabolism[MESH]
  • |Renin-Angiotensin System/*drug effects[MESH]


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