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10.1016/j.arcmed.2020.08.002

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32863034!7418647!32863034
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suck abstract from ncbi


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pmid32863034      Arch+Med+Res 2020 ; 51 (7): 631-635
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  • A Perspective on Erythropoietin as a Potential Adjuvant Therapy for Acute Lung Injury/Acute Respiratory Distress Syndrome in Patients with COVID-19 #MMPMID32863034
  • Sahebnasagh A; Mojtahedzadeh M; Najmeddin F; Najafi A; Safdari M; Rezai Ghaleno H; Habtemariam S; Berindan-Neagoe I; Nabavi SM
  • Arch Med Res 2020[Oct]; 51 (7): 631-635 PMID32863034show ga
  • The novel coronavirus 2019-nCoV (SARS-CoV-2) infection that emerged in China in December 2019 has rapidly spread to become a global pandemic. This article summarizes the potential benefits of erythropoietin (EPO) in alleviating SARS-CoV-2 pathogenesis which is now called COVID-19. As with other coronavirus infection, the lethality of COVID-19 is associated with respiratory dysfunction due to overexpression of proinflammatory cytokines induced by the host immune responses. The resulting cytokine storm leads to the development of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Erythropoietin, well known for its role in the regulation of erythropoiesis, may have protective effects against ALI/ARDS induced by viral and other pathogens. EPO exerts antiapoptotic and cytoprotective properties under various pathological conditions. With a high safety profile, EPO promotes the production of endothelial progenitor cells and reduce inflammatory processes through inhibition of the nuclear factor-kappaB (NF-kappaB) and JAK-STAT3 signaling pathways. Thus, it may be considered as a safe drug candidate for COVID-19 patients if given at the early stage of the disease. The potential effects of erythropoietin on different aspects of ALI/ARDS associated with SARS-CoV-2 infection are reviewed.
  • |*Acute Lung Injury/drug therapy/virology[MESH]
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/complications[MESH]
  • |*Respiratory Distress Syndrome/drug therapy/virology[MESH]
  • |Anti-Inflammatory Agents/*therapeutic use[MESH]
  • |Cytokine Release Syndrome/drug therapy/virology[MESH]
  • |Erythropoietin/*therapeutic use[MESH]
  • |Humans[MESH]


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