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10.1016/j.jaip.2020.08.026 http://scihub22266oqcxt.onion/10.1016/j.jaip.2020.08.026 32861856!7450283!32861856     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol+Pract 2020 ; 8 (10): 3251-3258 Nephropedia Template TP {{tp|p=32861856|t=2020. Age-Related Differences in Immunological Responses to SARS-CoV-2 |pdf=|usr=}}{{32861856}} gab.com Text Age-Related Differences in Immunological Responses to SARS-CoV-2 JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=32861856 #FOAvip There is a striking age-related disparity in the prevalence and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 infections, which might be explained by age-dependent immunological mechanisms. These include age-related physiological differences in immunological responses, cross-neutralizing antibodies, and differences in levels and binding affinity of angiotensin-converting enzyme 2, the SARS-CoV-2 target receptor; antibody-dependent enhancement in adults manifesting with an overexuberant systemic inflammation in response to infection; and the increased likelihood of comorbidities in adults and the elderly. Emerging immunological phenomena such as Pediatric Multi-System Inflammatory Disorder Temporally associated with SARS-CoV-2 or Multisystem Inflammatory Syndrome in Children are now being observed, though the underlying mechanisms are still unclear. Understanding the mechanisms through which pediatric patients are protected from severe novel coronaviruses infections will provide critical clues to the pathophysiology of coronavirus disease 2019 infection and inform future therapeutic and prophylactic interventions. Asymptomatic carriage in children may have major public health implications, which will have an impact on social and health care policies on screening and isolation practices, school reopening, and safe distancing requirements in the community. Twit Text FOAVip Age-Related Differences in Immunological Responses to SARS-CoV-2 ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=32861856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32861856 #FOAvip English Wikipedia <ref>{{Cite pmid|32861856}}</ref> Age-Related Differences in Immunological Responses to SARS-CoV-2 #MMPMID32861856 Wong LSY; Loo EXL; Kang AYH; Lau HX; Tambyah PA; Tham EH J Allergy Clin Immunol Pract 2020[Nov]; 8 (10): 3251-3258 PMID32861856show ga There is a striking age-related disparity in the prevalence and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 infections, which might be explained by age-dependent immunological mechanisms. These include age-related physiological differences in immunological responses, cross-neutralizing antibodies, and differences in levels and binding affinity of angiotensin-converting enzyme 2, the SARS-CoV-2 target receptor; antibody-dependent enhancement in adults manifesting with an overexuberant systemic inflammation in response to infection; and the increased likelihood of comorbidities in adults and the elderly. Emerging immunological phenomena such as Pediatric Multi-System Inflammatory Disorder Temporally associated with SARS-CoV-2 or Multisystem Inflammatory Syndrome in Children are now being observed, though the underlying mechanisms are still unclear. Understanding the mechanisms through which pediatric patients are protected from severe novel coronaviruses infections will provide critical clues to the pathophysiology of coronavirus disease 2019 infection and inform future therapeutic and prophylactic interventions. Asymptomatic carriage in children may have major public health implications, which will have an impact on social and health care policies on screening and isolation practices, school reopening, and safe distancing requirements in the community. |*Age Factors[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibody-Dependent Enhancement/*immunology[MESH] |Asymptomatic Infections[MESH] |B-Lymphocytes/immunology[MESH] |Betacoronavirus/*immunology[MESH] |Broadly Neutralizing Antibodies/*immunology[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Comorbidity[MESH] |Coronavirus Infections/epidemiology/*immunology/transmission[MESH] |Cytokine Release Syndrome/*immunology[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Immunosenescence/*immunology[MESH] |Infant[MESH] |Inflammation/immunology[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/epidemiology/*immunology/transmission[MESH] |Policy Making[MESH] |Renin-Angiotensin System/immunology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |Systemic Inflammatory Response Syndrome/*immunology[MESH] |T-Lymphocytes/immunology[MESH]Age-Related Differences in Immunological Responses to SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing