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10.1016/j.mayocp.2020.06.028

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2020.06.028
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32861333!7368917!32861333
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suck abstract from ncbi


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pmid32861333      Mayo+Clin+Proc 2020 ; 95 (9): 1888-1897
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  • Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients #MMPMID32861333
  • Joyner MJ; Bruno KA; Klassen SA; Kunze KL; Johnson PW; Lesser ER; Wiggins CC; Senefeld JW; Klompas AM; Hodge DO; Shepherd JRA; Rea RF; Whelan ER; Clayburn AJ; Spiegel MR; Baker SE; Larson KF; Ripoll JG; Andersen KJ; Buras MR; Vogt MNP; Herasevich V; Dennis JJ; Regimbal RJ; Bauer PR; Blair JE; van Buskirk CM; Winters JL; Stubbs JR; van Helmond N; Butterfield BP; Sexton MA; Diaz Soto JC; Paneth NS; Verdun NC; Marks P; Casadevall A; Fairweather D; Carter RE; Wright RS
  • Mayo Clin Proc 2020[Sep]; 95 (9): 1888-1897 PMID32861333show ga
  • OBJECTIVE: To provide an update on key safety metrics after transfusion of convalescent plasma in hospitalized coronavirus 2019 (COVID-19) patients, having previously demonstrated safety in 5000 hospitalized patients. PATIENTS AND METHODS: From April 3 to June 2, 2020, the US Food and Drug Administration Expanded Access Program for COVID-19 convalescent plasma transfused a convenience sample of 20,000 hospitalized patients with COVID-19 convalescent plasma. RESULTS: The incidence of all serious adverse events was low; these included transfusion reactions (n=78; <1%), thromboembolic or thrombotic events (n=113; <1%), and cardiac events (n=677, ~3%). Notably, the vast majority of the thromboembolic or thrombotic events (n=75) and cardiac events (n=597) were judged to be unrelated to the plasma transfusion per se. The 7-day mortality rate was 13.0% (12.5%, 13.4%), and was higher among more critically ill patients relative to less ill counterparts, including patients admitted to the intensive care unit versus those not admitted (15.6 vs 9.3%), mechanically ventilated versus not ventilated (18.3% vs 9.9%), and with septic shock or multiple organ dysfunction/failure versus those without dysfunction/failure (21.7% vs 11.5%). CONCLUSION: These updated data provide robust evidence that transfusion of convalescent plasma is safe in hospitalized patients with COVID-19, and support the notion that earlier administration of plasma within the clinical course of COVID-19 is more likely to reduce mortality.
  • |*Patient Safety[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Adverse Drug Reaction Reporting Systems[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Coronavirus Infections/mortality/*therapy[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/mortality/*therapy[MESH]
  • |United States[MESH]


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