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10.1016/j.biopha.2020.110678 http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110678 32861070!7444942!32861070     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2020 ; 131 (ä): 110678 Nephropedia Template TP {{tp|p=32861070|t=2020. ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 |pdf=|usr=}}{{32861070}} gab.com Text ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=32861070 #FOAvip At the end of 2019, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Currently, it is breaking out globally and posing a serious threat to public health. The typically clinical characteristics of COVID-19 patients were fever and respiratory symptoms, and a proportion of patients were accompanied by extrapulmonary symptoms including cardiac injury, kidney injury, liver injury, digestive tract injury, and neurological symptoms. Angiotensin converting enzyme 2 (ACE2) has been proven to be a major receptor for SARS-CoV-2 and could mediate virus entry into cells. And transmembrane protease serine 2 (TMPRSS2) could cleave the spike (S) protein of SARS-CoV-2, which facilitates the fusion of SARS-CoV-2 and cellular membranes. The mRNA expressions of both ACE2 and TMPRSS2 were observed in the heart, digestive tract, liver, kidney, brain and other organs. SARS-CoV-2 may have a capacity to infect extrapulmonary organs due to the expressions of ACE2 and TMPRSS2 in the cells and tissues of these organs. It seems that there is a potential involvement of ACE2 and TMPRSS2 expressions in the virus infection of extrapulmonary organs and the manifestation of symptoms related to these organs in patients with COVID-19. Here, we revealed the expressions of ACE2 and TMPRSS2 in extrapulmonary organs, and we also summarized the clinical manifestation and the management of extrapulmonary complications in patients with COVID-19. Twit Text FOAVip ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=32861070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32861070 #FOAvip English Wikipedia <ref>{{Cite pmid|32861070}}</ref> ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 #MMPMID32861070 Dong M; Zhang J; Ma X; Tan J; Chen L; Liu S; Xin Y; Zhuang L Biomed Pharmacother 2020[Nov]; 131 (ä): 110678 PMID32861070show ga At the end of 2019, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Currently, it is breaking out globally and posing a serious threat to public health. The typically clinical characteristics of COVID-19 patients were fever and respiratory symptoms, and a proportion of patients were accompanied by extrapulmonary symptoms including cardiac injury, kidney injury, liver injury, digestive tract injury, and neurological symptoms. Angiotensin converting enzyme 2 (ACE2) has been proven to be a major receptor for SARS-CoV-2 and could mediate virus entry into cells. And transmembrane protease serine 2 (TMPRSS2) could cleave the spike (S) protein of SARS-CoV-2, which facilitates the fusion of SARS-CoV-2 and cellular membranes. The mRNA expressions of both ACE2 and TMPRSS2 were observed in the heart, digestive tract, liver, kidney, brain and other organs. SARS-CoV-2 may have a capacity to infect extrapulmonary organs due to the expressions of ACE2 and TMPRSS2 in the cells and tissues of these organs. It seems that there is a potential involvement of ACE2 and TMPRSS2 expressions in the virus infection of extrapulmonary organs and the manifestation of symptoms related to these organs in patients with COVID-19. Here, we revealed the expressions of ACE2 and TMPRSS2 in extrapulmonary organs, and we also summarized the clinical manifestation and the management of extrapulmonary complications in patients with COVID-19. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/virology[MESH] |Gene Expression Regulation, Enzymologic[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH] |Pneumonia, Viral/*complications/virology[MESH] |RNA, Messenger/genetics[MESH] |SARS-CoV-2[MESH]ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients(epmc).pdf DeepDyve Pubget Overpricing