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10.1093/infdis/jiaa553

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa553
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32860509!7499673!32860509
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suck abstract from ncbi


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pmid32860509      J+Infect+Dis 2021 ; 223 (9): 1564-1575
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  • Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation #MMPMID32860509
  • Pinana JL; Xhaard A; Tridello G; Passweg J; Kozijn A; Polverelli N; Heras I; Perez A; Sanz J; Berghuis D; Vazquez L; Suarez-Lledo M; Itala-Remes M; Ozcelik T; Iturrate Basaran I; Karakukcu M; Al Zahrani M; Choi G; Cuesta Casas MA; Batlle Massana M; Viviana A; Blijlevens N; Ganser A; Kuskonmaz B; Labussiere-Wallet H; Shaw PJ; Yegin ZA; Gonzalez-Vicent M; Rocha V; Ferster A; Knelange N; Navarro D; Mikulska M; de la Camara R; Styczynski J
  • J Infect Dis 2021[May]; 223 (9): 1564-1575 PMID32860509show ga
  • BACKGROUND: Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). METHODS: This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. RESULTS: We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 x 109/mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01). CONCLUSIONS: Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
  • |*Hematopoietic Stem Cell Transplantation[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus 229E, Human[MESH]
  • |Coronavirus Infections/*complications/*epidemiology/mortality[MESH]
  • |Coronavirus NL63, Human[MESH]
  • |Coronavirus OC43, Human[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Respiratory Tract Infections/*epidemiology/*etiology/mortality[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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