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10.1111/eci.13378

http://scihub22266oqcxt.onion/10.1111/eci.13378
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suck abstract from ncbi


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pmid32860457      Eur+J+Clin+Invest 2020 ; 50 (10): e13378
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  • Features of severe COVID-19: A systematic review and meta-analysis #MMPMID32860457
  • Del Sole F; Farcomeni A; Loffredo L; Carnevale R; Menichelli D; Vicario T; Pignatelli P; Pastori D
  • Eur J Clin Invest 2020[Oct]; 50 (10): e13378 PMID32860457show ga
  • BACKGROUND: To systematically review clinical and biochemical characteristics associated with the severity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease (COVID-19). MATERIALS AND METHODS: Systematic review of observational studies from PubMed, ISI Web of Science, SCOPUS and Cochrane databases including people affected by COVID-19 and reporting data according to the severity of the disease. Data were combined with odds ratio (OR) and metanalysed. Severe COVID-19 was defined by acute respiratory distress syndrome, intensive care unit admission and death. RESULTS: We included 12 studies with 2794 patients, of whom 596 (21.33%) had severe disease. A slightly higher age was found in severe vs non-severe disease. We found that prevalent cerebrovascular disease (odds ratio [OR] 3.66, 95% confidence interval [CI] 1.73-7.72), chronic obstructive pulmonary disease (OR: 2.39, 95% CI 1.10-5.19), prevalent cardiovascular disease (OR: 2.84, 95% CI 1.59-5.10), diabetes (OR: 2.78, 95% CI 2.09-3.72), hypertension (OR: 2.24, 95% CI 1.63-3.08), smoking (OR: 1.54, 95% CI 1.07-2.22) and male sex (OR: 1.22, 95% CI 1.01-1.49) were associated with severe disease. Furthermore, increased procalcitonin (OR: 8.21, 95% CI 4.48-15.07), increased D-Dimer (OR: 5.67, 95% CI 1.45-22.16) and thrombocytopenia (OR: 3.61, 95% CI 2.62-4.97) predicted severe infection. CONCLUSION: Characteristics associated with the severity of SARS-CoV-2 infection may allow an early identification and management of patients with poor outcomes.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/*epidemiology[MESH]
  • |Cerebrovascular Disorders/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/epidemiology/*metabolism/physiopathology[MESH]
  • |Diabetes Mellitus/*epidemiology[MESH]
  • |Fibrin Fibrinogen Degradation Products/*metabolism[MESH]
  • |Humans[MESH]
  • |Hypertension/epidemiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/*metabolism/physiopathology[MESH]
  • |Prevalence[MESH]
  • |Procalcitonin/*metabolism[MESH]
  • |Pulmonary Disease, Chronic Obstructive/*epidemiology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Sex Factors[MESH]
  • |Smoking/*epidemiology[MESH]


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