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10.4103/ijmr.IJMR_2382_20 http://scihub22266oqcxt.onion/10.4103/ijmr.IJMR_2382_20 32859866!7853248!32859866     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Indian+J+Med+Res 2020 ; 152 (1 & 2): 82-87 Nephropedia Template TP {{tp|p=32859866|t=2020. Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients |pdf=|usr=}}{{32859866}} gab.com Text Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients JO: Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32859866 #FOAvip BACKGROUND & OBJECTIVES: The global pandemic caused by SARS-CoV-2 virus has challenged public health system worldwide due to the unavailability of approved preventive and therapeutic options. Identification of neutralizing antibodies (NAb) and understanding their role is important. However, the data on kinetics of NAb response among COVID-19 patients are unclear. To understand the NAb response in COVID-19 patients, we compared the findings of microneutralization test (MNT) and plaque reduction neutralization test (PRNT) for the SARS-CoV-2. Further, the kinetics of NAb response among COVID-19 patients was assessed. METHODS: A total of 343 blood samples (89 positive, 58 negative for SARS-CoV-2 and 17 cross-reactive and 179 serum from healthy individuals) were collected and tested by MNT and PRNT. SARS-CoV-2 virus was prepared by propagating the virus in Vero CCL-81 cells. The intra-class correlation was calculated to assess the correlation between MNT and PRNT. The neutralizing endpoint as the reduction in the number of plaque count by 90 per cent (PRNT(90)) was also calculated. RESULTS: The analysis of MNT and PRNT quantitative results indicated that the intra-class correlation was 0.520. Of the 89 confirmed COVID-19 patients, 64 (71.9%) showed NAb response. INTERPRETATION & CONCLUSIONS: The results of MNT and PRNT were specific with no cross-reactivity. In the early stages of infection, the NAb response was observed with variable antibody kinetics. The neutralization assays can be used for titration of NAb in recovered/vaccinated or infected COVID-19 patients. Twit Text FOAVip Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients ????Indian J Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32859866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32859866 #FOAvip English Wikipedia <ref>{{Cite pmid|32859866}}</ref> Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients #MMPMID32859866 Deshpande GR; Sapkal GN; Tilekar BN; Yadav PD; Gurav Y; Gaikwad S; Kaushal H; Deshpande KS; Kaduskar O; Sarkale P; Baradkar S; Suryawanshi A; Lakra R; Sugunan AP; Balakrishnan A; Abraham P; Salve P Indian J Med Res 2020[Jul]; 152 (1 & 2): 82-87 PMID32859866show ga BACKGROUND & OBJECTIVES: The global pandemic caused by SARS-CoV-2 virus has challenged public health system worldwide due to the unavailability of approved preventive and therapeutic options. Identification of neutralizing antibodies (NAb) and understanding their role is important. However, the data on kinetics of NAb response among COVID-19 patients are unclear. To understand the NAb response in COVID-19 patients, we compared the findings of microneutralization test (MNT) and plaque reduction neutralization test (PRNT) for the SARS-CoV-2. Further, the kinetics of NAb response among COVID-19 patients was assessed. METHODS: A total of 343 blood samples (89 positive, 58 negative for SARS-CoV-2 and 17 cross-reactive and 179 serum from healthy individuals) were collected and tested by MNT and PRNT. SARS-CoV-2 virus was prepared by propagating the virus in Vero CCL-81 cells. The intra-class correlation was calculated to assess the correlation between MNT and PRNT. The neutralizing endpoint as the reduction in the number of plaque count by 90 per cent (PRNT(90)) was also calculated. RESULTS: The analysis of MNT and PRNT quantitative results indicated that the intra-class correlation was 0.520. Of the 89 confirmed COVID-19 patients, 64 (71.9%) showed NAb response. INTERPRETATION & CONCLUSIONS: The results of MNT and PRNT were specific with no cross-reactivity. In the early stages of infection, the NAb response was observed with variable antibody kinetics. The neutralization assays can be used for titration of NAb in recovered/vaccinated or infected COVID-19 patients. |*Neutralization Tests[MESH] |*Pandemics[MESH] |Adolescent[MESH] |Adult[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology/*isolation & purification[MESH] |Antibodies, Viral/blood[MESH] |Betacoronavirus/immunology/pathogenicity[MESH] |COVID-19[MESH] |Child[MESH] |Chlorocebus aethiops/immunology[MESH] |Coronavirus Infections/*blood/epidemiology/immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pneumonia, Viral/*blood/epidemiology/immunology/virology[MESH] |SARS-CoV-2[MESH] |Vero Cells/immunology[MESH]Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing