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10.14309/ajg.0000000000000828

http://scihub22266oqcxt.onion/10.14309/ajg.0000000000000828
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32858566!7473797!32858566
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suck abstract from ncbi


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pmid32858566      Am+J+Gastroenterol 2020 ; 115 (10): 1716-1718
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  • Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice #MMPMID32858566
  • Levy C; Lassailly G; Parmentier E; Duburcq T; Mathurin P; Poissy J
  • Am J Gastroenterol 2020[Oct]; 115 (10): 1716-1718 PMID32858566show ga
  • INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. METHODS: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group. RESULTS: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%). DISCUSSION: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.
  • |Aged[MESH]
  • |Antiviral Agents/*adverse effects[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/diagnosis/*drug therapy/virology[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Drug Administration Schedule[MESH]
  • |Drug Combinations[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Jaundice/*chemically induced/diagnosis/epidemiology[MESH]
  • |Lopinavir/administration & dosage/*adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/virology[MESH]
  • |Prospective Studies[MESH]
  • |Retrospective Studies[MESH]
  • |Ritonavir/administration & dosage/*adverse effects[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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