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10.1016/j.jad.2020.08.031

http://scihub22266oqcxt.onion/10.1016/j.jad.2020.08.031
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32858315!7439825!32858315
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suck abstract from ncbi

pmid32858315      J+Affect+Disord 2020 ; 277 (?): 337-340
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  • First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder #MMPMID32858315
  • Lu S; Wei N; Jiang J; Wu L; Sheng J; Zhou J; Fang Q; Chen Y; Zheng S; Chen F; Liang T; Hu S
  • J Affect Disord 2020[Dec]; 277 (?): 337-340 PMID32858315show ga
  • BACKGROUND: In December 2019, the novel coronavirus (SARS-CoV-2) infection was first reported in Wuhan city, central China, which has spread rapidly. The common clinical features of patients with SARS-CoV-2 infection included fever, fatigue, and damage to the respiratory or digestive system. However, it is still unclear whether SARS-CoV-2 infection could cause damage to the central nervous system (CNS) inducing psychiatric symptoms. CASE REPORT: Herein, we present the first case of SARS-CoV-2 infection with manic-like symptoms and describe the diagnosis, clinical course, and treatment of the case, focusing on the identifications of SARS-CoV-2 in the specimen of cerebrospinal fluid (CSF). The patient developed manic-like symptoms when his vital signs recovered on illness day 17. After manic-like attack, the detection of SARS-CoV-2 specific IgG antibody in CSF was positive, while the reverse transcriptase-polymerase chain reaction (RT-PCR) on CSF for the SARS-CoV-2 was negative. The patient received Olanzapine for treatment and his mood problems concurrently improved as indicated by scores of Young Manic Rating Scale (YMRS). LIMITATION: This is a single case report only, and the RT-PCR test for SARS-CoV-2 in CSF was not performed simultaneously when SARS-CoV-2 was positive in samples of sputum and stool. CONCLUSION: This first case of COVID-19 patient with manic-like symptoms highlights the importance of evaluation of mental health status and may contribute to our understanding of potential risk of CNS impairments by SARS-CoV-2 infection.
  • |Antibodies, Viral/cerebrospinal fluid[MESH]
  • |Antipsychotic Agents/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |Bipolar Disorder/cerebrospinal fluid/diagnosis/drug therapy/*etiology[MESH]
  • |Brain/diagnostic imaging[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Chest Pain[MESH]
  • |China[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Cobicistat/therapeutic use[MESH]
  • |Coronavirus Infections/cerebrospinal fluid/*complications/diagnosis/therapy[MESH]
  • |Darunavir/therapeutic use[MESH]
  • |Dyspnea[MESH]
  • |Fever[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Indoles/therapeutic use[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Male[MESH]
  • |Methylprednisolone/therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Moxifloxacin/therapeutic use[MESH]
  • |Olanzapine/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pharyngitis[MESH]
  • |Pneumonia, Viral/cerebrospinal fluid/*complications/diagnosis/therapy[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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