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10.1371/journal.pone.0238490 http://scihub22266oqcxt.onion/10.1371/journal.pone.0238490 32857808!7454988!32857808     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (8): e0238490 Nephropedia Template TP {{tp|p=32857808|t=2020. SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2 |pdf=|usr=}}{{32857808}} gab.com Text SNPs or RNA modifications Concerns on mutation-based evolutionary studies of SARS-CoV-2 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32857808 #FOAvip SARS-CoV-2 is still rampaging throughout the world while the many evolutionary studies on it are simultaneously springing up. Researchers have simply utilized the public RNA-seq data to find out the so-called SNPs in the virus genome. The evolutionary analyses were largely based on these mutations. Here, we claim that we reliably detected A-to-G RNA modifications in the RNA-seq data of SARS-CoV-2 with high signal to noise ratios, presumably caused by the host's deamination enzymes. Intriguingly, since SARS-CoV-2 is an RNA virus, it is technically impossible to distinguish SNPs and RNA modifications from the RNA-seq data alone without solid evidence, making it difficult to tell the evolutionary patterns behind the mutation spectrum. Researchers should clarify their biological significance before they automatically regard the mutations as SNPs or RNA modifications. This is not a problem for DNA organisms but should be seriously considered when we are investigating the RNA viruses. Twit Text FOAVip SNPs or RNA modifications Concerns on mutation-based evolutionary studies of SARS-CoV-2 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32857808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32857808 #FOAvip English Wikipedia <ref>{{Cite pmid|32857808}}</ref> SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2 #MMPMID32857808 Li Y; Yang X; Wang N; Wang H; Yin B; Yang X; Jiang W PLoS One 2020[]; 15 (8): e0238490 PMID32857808show ga SARS-CoV-2 is still rampaging throughout the world while the many evolutionary studies on it are simultaneously springing up. Researchers have simply utilized the public RNA-seq data to find out the so-called SNPs in the virus genome. The evolutionary analyses were largely based on these mutations. Here, we claim that we reliably detected A-to-G RNA modifications in the RNA-seq data of SARS-CoV-2 with high signal to noise ratios, presumably caused by the host's deamination enzymes. Intriguingly, since SARS-CoV-2 is an RNA virus, it is technically impossible to distinguish SNPs and RNA modifications from the RNA-seq data alone without solid evidence, making it difficult to tell the evolutionary patterns behind the mutation spectrum. Researchers should clarify their biological significance before they automatically regard the mutations as SNPs or RNA modifications. This is not a problem for DNA organisms but should be seriously considered when we are investigating the RNA viruses. |*Evolution, Molecular[MESH] |*Polymorphism, Single Nucleotide[MESH] |Base Sequence[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections[MESH] |Humans[MESH] |Mutation Rate[MESH] |Pandemics[MESH] |Pneumonia, Viral[MESH] |RNA, Viral/*genetics[MESH] |RNA-Seq[MESH]SNPs or RNA modifications? Concerns on mutation-based evolutionary stu(epmc).pdf DeepDyve Pubget Overpricing