Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1093/cid/ciaa1280 http://scihub22266oqcxt.onion/10.1093/cid/ciaa1280 32856707!7499509!32856707     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Infect+Dis 2021 ; 73 (9): e2932-e2942 Nephropedia Template TP {{tp|p=32856707|t=2021. Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity |pdf=|usr=}}{{32856707}} gab.com Text Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity JO: Clin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32856707 #FOAvip BACKGROUND: Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. METHODS: We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% with comorbidities). Respiratory samples (n = 74) were collected for viral culture, serum samples for measurement of IgM/IgG levels (n = 30), and plasma samples for levels of inflammatory cytokines and chemokines (n = 81). Disease severity was correlated with results from viral culture, serologic testing, and immune markers. RESULTS: Fifty-seven (57%) patients developed viral pneumonia, of whom 20 (20%) required supplemental oxygen, including 12 (12%) with invasive mechanical ventilation. Viral culture from respiratory samples was positive for 19 of 74 patients (26%). No virus was isolated when the PCR cycle threshold (Ct) value was >30 or >14 days after symptom onset. Seroconversion occurred at a median (IQR) of 12.5 (9-18) days for IgM and 15.0 (12-20) days for IgG; 54/62 patients (87.1%) sampled at day 14 or later seroconverted. Severe infections were associated with earlier seroconversion and higher peak IgM and IgG levels. Levels of IP-10, HGF, IL-6, MCP-1, MIP-1alpha, IL-12p70, IL-18, VEGF-A, PDGF-BB, and IL-1RA significantly correlated with disease severity. CONCLUSIONS: We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials. Twit Text FOAVip Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity ????Clin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32856707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32856707 #FOAvip English Wikipedia <ref>{{Cite pmid|32856707}}</ref> Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity #MMPMID32856707 Young BE; Ong SWX; Ng LFP; Anderson DE; Chia WN; Chia PY; Ang LW; Mak TM; Kalimuddin S; Chai LYA; Pada S; Tan SY; Sun L; Parthasarathy P; Fong SW; Chan YH; Tan CW; Lee B; Rotzschke O; Ding Y; Tambyah P; Low JGH; Cui L; Barkham T; Lin RTP; Leo YS; Renia L; Wang LF; Lye DC Clin Infect Dis 2021[Nov]; 73 (9): e2932-e2942 PMID32856707show ga BACKGROUND: Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. METHODS: We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% with comorbidities). Respiratory samples (n = 74) were collected for viral culture, serum samples for measurement of IgM/IgG levels (n = 30), and plasma samples for levels of inflammatory cytokines and chemokines (n = 81). Disease severity was correlated with results from viral culture, serologic testing, and immune markers. RESULTS: Fifty-seven (57%) patients developed viral pneumonia, of whom 20 (20%) required supplemental oxygen, including 12 (12%) with invasive mechanical ventilation. Viral culture from respiratory samples was positive for 19 of 74 patients (26%). No virus was isolated when the PCR cycle threshold (Ct) value was >30 or >14 days after symptom onset. Seroconversion occurred at a median (IQR) of 12.5 (9-18) days for IgM and 15.0 (12-20) days for IgG; 54/62 patients (87.1%) sampled at day 14 or later seroconverted. Severe infections were associated with earlier seroconversion and higher peak IgM and IgG levels. Levels of IP-10, HGF, IL-6, MCP-1, MIP-1alpha, IL-12p70, IL-18, VEGF-A, PDGF-BB, and IL-1RA significantly correlated with disease severity. CONCLUSIONS: We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials. |*COVID-19[MESH] |*Pneumonia, Viral[MESH] |Antibodies, Viral[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin M[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH]Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVI(epmc).pdf DeepDyve Pubget Overpricing