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10.1093/infdis/jiaa550

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa550
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32856702!7499595!32856702
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suck abstract from ncbi


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pmid32856702      J+Infect+Dis 2020 ; 222 (11): 1794-1797
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  • The Fibrosis-4 Index Is Associated With Need for Mechanical Ventilation and 30-Day Mortality in Patients Admitted With Coronavirus Disease 2019 #MMPMID32856702
  • Sterling RK; Oakes T; Gal TS; Stevens MP; deWit M; Sanyal AJ
  • J Infect Dis 2020[Nov]; 222 (11): 1794-1797 PMID32856702show ga
  • The Fibrosis-4 Index (FIB-4), developed to predict fibrosis in liver disease, was used to identify patients with coronavirus disease 2019 who will require ventilator support as well as those associated with 30-day mortality. Multivariate analysis found obesity (odds ratio [OR], 4.5), diabetes mellitus (OR, 2.55), and FIB-4 >/=2.67 (OR, 3.09) independently associated with need for mechanical ventilation. When controlling for ventilator use, sex, and comorbid conditions, FIB-4 >/=2.67 was also associated with increased 30-day mortality (OR, 8.4 [95% confidence interval, 2.23-31.7]). Although it may not be measuring hepatic fibrosis, its components suggest that increases in FIB-4 may be reflecting systemic inflammation associated with poor outcomes.
  • |*Respiration, Artificial[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/mortality/*pathology/*therapy[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Liver Diseases/mortality/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Odds Ratio[MESH]
  • |Respiratory Insufficiency/pathology/therapy/virology[MESH]


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