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10.1093/ofid/ofaa326

http://scihub22266oqcxt.onion/10.1093/ofid/ofaa326
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32855992!7443106!32855992
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suck abstract from ncbi


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pmid32855992      Open+Forum+Infect+Dis 2020 ; 7 (8): ofaa326
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  • A Case of Steroid-Responsive, COVID-19 Immune Reconstitution Inflammatory Syndrome Following the Use of Granulocyte Colony-Stimulating Factor #MMPMID32855992
  • Mertens J; Laghrib Y; Kenyon C
  • Open Forum Infect Dis 2020[Aug]; 7 (8): ofaa326 PMID32855992show ga
  • We present a case report of a 54-year-old male with metastasized nasopharyngeal carcinoma presenting to the hospital with dyspnea, anorexia and fever. Examination revealed chemotherapy-induced pancytopenia. The patient tested positive for SARSCoV-2, but respiratory complications were mild. The patient was treated with granulocyte-colony stimulating factor (G-CSF) leading to amelioration of the neutropenia. However, severe acute respiratory distress syndrome (ARDS) occurred, prompting the diagnosis of immune reconstitution inflammatory syndrome (IRIS). GCSF is currently investigated as additional therapy in ARDS, but this case report emphasizes that risks and benefits must be carefully assessed. To our knowledge, this is the first case report of IRIS-induced ARDS in a COVID-19 patient.
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