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10.1126/science.abb3753 http://scihub22266oqcxt.onion/10.1126/science.abb3753 32855215!7665841!32855215     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 370 (6513): 241-247 Nephropedia Template TP {{tp|p=32855215|t=2020. MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses |pdf=|usr=}}{{32855215}} gab.com Text MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32855215 #FOAvip Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our poor understanding of the cellular mechanisms that block viral infections. Using a transposon-mediated gene-activation screen in human cells, we identify that the major histocompatibility complex (MHC) class II transactivator (CIITA) has antiviral activity against EBOV. CIITA induces resistance by activating expression of the p41 isoform of invariant chain CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the Ebola glycoprotein. We further show that CD74 p41 can block the endosomal entry pathway of coronaviruses, including SARS-CoV-2. These data therefore implicate CIITA and CD74 in host defense against a range of viruses, and they identify an additional function of these proteins beyond their canonical roles in antigen presentation. Twit Text FOAVip MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32855215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32855215 #FOAvip English Wikipedia <ref>{{Cite pmid|32855215}}</ref> MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses #MMPMID32855215 Bruchez A; Sha K; Johnson J; Chen L; Stefani C; McConnell H; Gaucherand L; Prins R; Matreyek KA; Hume AJ; Muhlberger E; Schmidt EV; Olinger GG; Stuart LM; Lacy-Hulbert A Science 2020[Oct]; 370 (6513): 241-247 PMID32855215show ga Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our poor understanding of the cellular mechanisms that block viral infections. Using a transposon-mediated gene-activation screen in human cells, we identify that the major histocompatibility complex (MHC) class II transactivator (CIITA) has antiviral activity against EBOV. CIITA induces resistance by activating expression of the p41 isoform of invariant chain CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the Ebola glycoprotein. We further show that CD74 p41 can block the endosomal entry pathway of coronaviruses, including SARS-CoV-2. These data therefore implicate CIITA and CD74 in host defense against a range of viruses, and they identify an additional function of these proteins beyond their canonical roles in antigen presentation. |*Virus Internalization[MESH] |Antigens, Differentiation, B-Lymphocyte/genetics/*physiology[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Cell Line, Tumor[MESH] |Coronavirus Infections/*immunology/virology[MESH] |DNA Transposable Elements[MESH] |Ebolavirus/*physiology[MESH] |Endosomes/virology[MESH] |Genetic Testing[MESH] |Hemorrhagic Fever, Ebola/*immunology/virology[MESH] |Histocompatibility Antigens Class II/genetics/*physiology[MESH] |Host-Pathogen Interactions/genetics/*immunology[MESH] |Humans[MESH] |Nuclear Proteins/genetics/*physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |SARS-CoV-2[MESH] |Trans-Activators/genetics/*physiology[MESH]MHC class II transactivator CIITA induces cell resistance to Ebola vir(epmc).pdf DeepDyve Pubget Overpricing