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10.1016/j.diabres.2020.108386

http://scihub22266oqcxt.onion/10.1016/j.diabres.2020.108386
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suck abstract from ncbi

pmid32853685      Diabetes+Res+Clin+Pract 2020 ; 169 (?): 108386
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  • The association of diabetes and the prognosis of COVID-19 patients: A retrospective study #MMPMID32853685
  • Liu Z; Bai X; Han X; Jiang W; Qiu L; Chen S; Yu X
  • Diabetes Res Clin Pract 2020[Nov]; 169 (?): 108386 PMID32853685show ga
  • AIMS: This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes. METHODS: In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Data and outcomes were extracted from medical records and analyzed. RESULTS: 64 patients with pre-existing diabetes were included in this study, with 128 matched patients without diabetes included as a control group. Patients with diabetes had a higher rate of worsening (18.8% versus 7.8%, p = 0.025). Multivariable regression showed increased odds of worsening associated with previous glycemic control reflected by HbA1c (odds ratio 3.29, 95% CI 1.19-9.13, p = 0.022) and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening. CONCLUSIONS: COVID-19 patients with diabetes had a higher risk of worsening, especially those with poorly-controlled HbA1c, with an optimal cut-off value of 8.6%. The in-hospital use of antidiabetic/antihypertensive drugs were not associated with increased odds of worsening in patients with diabetes.
  • |Aged[MESH]
  • |Antihypertensive Agents/*therapeutic use[MESH]
  • |COVID-19/*complications/transmission/virology[MESH]
  • |China/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Diabetes Mellitus/drug therapy/*epidemiology/virology[MESH]
  • |Female[MESH]
  • |Glycemic Index[MESH]
  • |Humans[MESH]
  • |Hypoglycemic Agents/*therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Patient Discharge[MESH]
  • |Prognosis[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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