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10.1016/j.molcel.2020.07.027

http://scihub22266oqcxt.onion/10.1016/j.molcel.2020.07.027
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32853546!7402271!32853546
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suck abstract from ncbi


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pmid32853546      Mol+Cell 2020 ; 79 (5): 710-727
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  • Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting #MMPMID32853546
  • Robson F; Khan KS; Le TK; Paris C; Demirbag S; Barfuss P; Rocchi P; Ng WL
  • Mol Cell 2020[Sep]; 79 (5): 710-727 PMID32853546show ga
  • The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nucleoside analogs (NAs), exert their effect by incorporation into viral genomes and subsequent disruption of viral replication and fidelity. The development of anti-CoV drugs has long been hindered by the capacity of CoVs to proofread and remove mismatched nucleotides during genome replication and transcription. Here, we review the molecular basis of the CoV proofreading complex and evaluate its potential as a drug target. We also consider existing nucleoside analogs and novel genomic techniques as potential anti-CoV therapeutics that could be used individually or in combination to target the proofreading mechanism.
  • |*Genome, Viral[MESH]
  • |*Pandemics[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/chemistry/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/chemistry/therapeutic use[MESH]
  • |Amides/chemistry/therapeutic use[MESH]
  • |Antiviral Agents/chemistry/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/genetics/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/*epidemiology/virology[MESH]
  • |Cytidine/analogs & derivatives[MESH]
  • |Humans[MESH]
  • |Hydroxylamines[MESH]
  • |Molecular Targeted Therapy/methods[MESH]
  • |Mutation[MESH]
  • |Pneumonia, Viral/*drug therapy/*epidemiology/virology[MESH]
  • |Pyrazines/chemistry/therapeutic use[MESH]
  • |RNA, Viral/antagonists & inhibitors/*genetics/metabolism[MESH]
  • |Ribonucleosides/chemistry/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Transcription, Genetic[MESH]
  • |Viral Nonstructural Proteins/antagonists & inhibitors/genetics/metabolism[MESH]


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