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10.1126/sciadv.abb7238 http://scihub22266oqcxt.onion/10.1126/sciadv.abb7238 32851183!7428331!32851183     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2020 ; 6 (33): eabb7238 Nephropedia Template TP {{tp|p=32851183|t=2020. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice |pdf=|usr=}}{{32851183}} gab.com Text Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32851183 #FOAvip Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of function of Miz1, which we identified as a negative regulator of nuclear factor kappaB (NF-kappaB) signaling, spontaneously develop progressive age-related changes resembling COPD. Furthermore, loss of Miz1 up-regulates the expression of Ace2, the receptor for SARS-CoV-2. Concomitant partial loss of NF-kappaB/RelA prevented the development of COPD-like phenotype in Miz1-deficient mice. Miz1 protein levels are reduced in the lungs from patients with COPD, and in the lungs of mice exposed to chronic cigarette smoke. Our data suggest that Miz1 down-regulation-induced sustained activation of NF-kappaB-dependent inflammation in the lung epithelium is sufficient to induce progressive lung and airway destruction that recapitulates features of COPD, with implications for COVID-19. Twit Text FOAVip Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32851183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32851183 #FOAvip English Wikipedia <ref>{{Cite pmid|32851183}}</ref> Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice #MMPMID32851183 Do-Umehara HC; Chen C; Zhang Q; Misharin AV; Abdala-Valencia H; Casalino-Matsuda SM; Reyfman PA; Anekalla KR; Gonzalez-Gonzalez FJ; Sala MA; Peng C; Wu P; Wong CCL; Kalhan R; Bharat A; Perlman H; Ridge KM; Sznajder JI; Sporn PHS; Chandel NS; Yu J; Fu X; Petrache I; Tuder R; Budinger GRS; Liu J Sci Adv 2020[Aug]; 6 (33): eabb7238 PMID32851183show ga Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of function of Miz1, which we identified as a negative regulator of nuclear factor kappaB (NF-kappaB) signaling, spontaneously develop progressive age-related changes resembling COPD. Furthermore, loss of Miz1 up-regulates the expression of Ace2, the receptor for SARS-CoV-2. Concomitant partial loss of NF-kappaB/RelA prevented the development of COPD-like phenotype in Miz1-deficient mice. Miz1 protein levels are reduced in the lungs from patients with COPD, and in the lungs of mice exposed to chronic cigarette smoke. Our data suggest that Miz1 down-regulation-induced sustained activation of NF-kappaB-dependent inflammation in the lung epithelium is sufficient to induce progressive lung and airway destruction that recapitulates features of COPD, with implications for COVID-19. |*Phenotype[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/metabolism/virology[MESH] |Epithelial Cells/*metabolism[MESH] |Gene Knockout Techniques[MESH] |Humans[MESH] |Kruppel-Like Transcription Factors/*metabolism[MESH] |Lung/*metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Pneumonia, Viral/metabolism/virology[MESH] |Protein Inhibitors of Activated STAT/*genetics/metabolism[MESH] |Pulmonary Disease, Chronic Obstructive/etiology/*genetics/metabolism[MESH] |SARS-CoV-2[MESH] |Signal Transduction/genetics[MESH] |Smoking/adverse effects[MESH] |Transcription Factor RelA/metabolism[MESH] |Ubiquitin-Protein Ligases/*genetics/metabolism[MESH]Epithelial cell-specific loss of function of Miz1 causes a spontaneous(epmc).pdf DeepDyve Pubget Overpricing